Guar gum interactions

GIT characteristics, either to improve or limit specific function, and thereby influence host health. However, the complex, multiple and varied nature of the combinations of phytochemicals present in plants and traditional herbal medicines has complicated efforts to better understand the specific interactions between phytochemicals and the GIT (Yuan and Lin, 2000). Phytochemicals have other applications, such as the use of guar gum as a vehicle to deliver therapeutics (Krishnaiah et al, 2001). 

The viscosities of solutions of xanthan, unlike those of all other water-soluble polymers, do not decrease as the temperature is raised. They are unaffected by temperature between 0 °C and 100 °C. And even though it is an anionic polymer, its solution viscosity is not affected by pH or most salts, i. e., although ionic, it behaves as if it were a neutral gum. Xanthan interacts synergistically with guar gum and locust bean gum (both galactomannans) (O Sect. 4.2). An increase in solution viscosity results from its interaction with guar gum. Heat-reversible gelation results from its interaction with locust bean gum. 

The viscosity of xanthan gum solutions is considerably increased, or gelation occurs, in the presence of some materials such as ceratonia, guar gum, and magnesium aluminum silicate. This effect is most pronounced in deionized water and is reduced by the presence of salt. This interaction may be desirable in some instances and can be exploited to reduce the amount of xanthan gum used in a formulation see Section 7. 

Structure determination of algal oligosaccharides Solid-state NMR study of interactions between guar gum and agarose... 

The clinical significance of this interaction is uncertain, but the reduction in serum levels is only small. It would clearly only be important if the reduced amount of penicillin absorbed was inadequate to control infection The effect of guar gum on other penicillins seems not to have been studied. 

It seems doubtful if any of these modest pharmacokinetic interactions has much, if any, clinical relevance because guar gum can improve the metabolic control and decrease serum lipids in patients with type 2 diabetes. ... 

Ricin, the toxin of Ricinus communis, has been adsorbed on guar gum, a polysaccharide containing D-galactosyl and D-mannosyl residues.The nonbinding toxic A chain is then isolated by reduction of the immobilized toxin with 2-mercaptoethanol, and the B chain is eluted with lactose. A nucleotidebinding domain in the A-chain was demonstrated from its interaction with Cibacron Blue F3GA. 

Interaction of xanthan with guar gum in solution leads to enhanced viscosity, whereas elastic thermo-reversible gels are obtained with LEG and konjac mannan sofP (Figure 26.5). Since xanthan may contain cellulases, it cannot be used with cellulose derivatives. 

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