Guanidine Compounds

Guanidine compounds, such as creatine, are 600-700 mg/kg fresh fish muscle tissue. In crustaceans, the role of creatine is taken over by arginine. 

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The definition of crop residues for thiamethoxam and thiacloprid includes the parent and its metabolite fV-(2-chlorothiazol-5-ylmethyl)-fV -methyl-A"-nitroguanidine (designated the guanidine compound) for thiamethoxam, and 3-(6-chloro-3-pyridylmethyl)-l,3-thiazolidin-2-ylideneaminocarboxamide (designated the amide compound) for thiacloprid (Figure 3). 

Amide compound of thiacloprid Guanidine compound of thiamethoxam Figure 3 Stmctures of metabolites of thiacloprid and thiamethoxam... 

Inamoto, Y. Inamoto, S. Hanai, T. Tokuda, M. Hatase, O. Yoshii, K. Sugiyama, N. Kinoshita, T. Liquid chromatography of guanidine compounds using a porous graphite carhon column and apphcation to their analysis in serum. J. Chromatogr., B 1998, 707, 111-120. 

Total synthesis of marine cyclic guanidine compounds and development of novel guanidine-type asymmetric organocatalysts 03YZ387. 

Numerous endogenous fluorescent substances are present in uremic sera and urine HPLC with fluorescence detection of uremic serum and urine passed through Centriflo CF 25 filter guanidine compound and amino acids removed... 

This summary of the physiologically active amidine and guanidine compounds clearly establishes the biological versatility of these related chemical groups. Many of the compounds have given temporarry excitement to their discoverers and then been dropped - the commonest experience in medicinal chemistry. However, there are important, clinically used, medicines in all the major categories of therapeutic action discussed in the review. 

Two weakly basic guanidine compounds have been isolated, monobromophakel-lin (51 R =Br, R = H) and dibromophakellin (51 R =R = Br) both were found to be present in the sponge as their hydrochlorides. ... 

The fluorescence of a ninhydrin derivative of creatine can be used to determine creatine concentrations in blood and urine. Protein and arginine are precipitated by treatment with barium hydroxide and zinc sulfate, and after addition of ninhydrin the solution is made basic and the fluorescence excited at 390 nm is monitored at 495 nm.Creatinine and phosphocrea-tine do not form fluorescent derivatives, but some guanidine compounds can interfere, although they are not normally present in significant amounts. 

Pietrzak, L, and Baczyk, K., 2001. Erythrocyte transketolase activity and guanidine compounds in hemodialysis patients. Kidney International. 59(Suppl. 78) S97-S101. 

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