Growth pattern, disordered

Courchesne E, Karns CM, Davis HR, Ziccardi R, Carper RA, Tigue ZD, Chisum HJ, Moses P, Pierce K, Lord C, Lincoln AJ, Pizzo S, Schreibman L, Haas RH, Akshoomoff NA, Courchesne RY (2001) Unusual brain growth patterns in early life in patients with autistic disorder an MRI study. Neurology 57 245-254. 

Dysplasia is a special type of cell adaptation that literally means disordered growth, and it is usually associated with neoplasia or preneoplastic changes. Dysplasia implies a loss in the uniformity of the individual cells and a loss in the normal tissue growth pattern. For example, a dysplastic area involving the epidermal layers of the skin might contain jumbled, atypical epithelial cells with loss of their normal polarity and orderly differentiation. 

Figure 2. Photograph showing the disordered growth pattern of a Ni St transformed colony...

R. Baumann, K. Kassner, C. Misbah, D. E. Temkin. Spatial subharmonics, irrational patterns, and disorder in eutectic growth. Phys Rev Lett 74 1597, 1995. 

Fig. 11. Amide F thermal denaturation spectra for ribonuclease A as followed by FTIR (left) and VCD (right), which show the IR peak shifting from the dominant /3-sheet frequency (skewed with a maximum at 1635 cm-1) to the random coil frequency ( 1645-1650 cm-1) and the VCD shape changing from the W-pattern characteristic of an a + p structure to a broadened negative couplet typical of a more disordered coil form. The process clearly indicates loss of one form and gain of another while encompassing recognition of an intermediate form. (This is seen here most easily as the decay and growth back of the 1630 cm-1 VCD feature, but is more obvious after factor analysis of the data set, Fig. 15).

Neoplasms are, as we noted in Chapter 3, new growths. But they are new in several highly destructive ways. Normal processes of cell replication within tissues occur in orderly, well-controlled ways. Neoplastic cells replicate wildly, without apparent controls. The relationships between the various types of cells within an organ are, if the organ is to function properly, also orderly neoplastic cells, because of their disorderly replication patterns, can disrupt normal architecture and organ dysfunction can ensue. 

The results presented in this section further illustrate that there is a considerable dependence of the band alignment at the CdS/ZnO interface on the details of its preparation. An important factor is the local structure of the ZnO film. There is considerable local disorder when the films are deposited at room temperature in pure Ar, deposition conditions that are often used in thin film solar cells. It is recalled that the disorder is only on a local scale and does not affect the long range order of the films, as obvious from clear X-ray diffraction patterns recorded from such films (see discussion in Sect. 4.2.3.3). Growth of sputter deposited ZnO on CdS always results in an amorphous nucleation layer at the interface. The amorphous nucleation layer affects the valence band offset. 

In 2004 Okrm and colleagues studied the role of cytokines and growth hormone in the regulation of sleep and narcolepsy. Collectively, proinflammatory cytokines and human growth hormone (HGH), were found to be possibly involved in the development of or the exacerbation of narcolepsy (a disabling neurological sleep disorder characterized by excessive daytime sleepiness and abnormal sleep manifestations). As the role of the immune system in sleep becomes clearer, a better interpretation will be available to assess why narcoleptics have altered cytokine and HGH levels. Future studies should be conducted to fuUy characterize the sources, patterns, and significance of alterations in patterns of proinflammatory cytokines and HGH in narcolepsy. ... 

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