Growth hormone biological effects

Table 11.5 Some of the major biological effects promoted by growth hormone. Although many of these are direct, other effects are mediated via IGF-1 (Chapter 10)...

Pikal, M. J., Dellermann, K., Roy, M. L Formulation and stability of freeze-dried proteins Effects of moisture and oxygen on the freeze-dried formulation of human growth hormones. Developments in Biological Standardization, Vol. 74, p. 21-38. Acting Editors Joan C. May - F. Brown. S. Karger AG, CH-4009 Basel (Switzerland), 1992... 

For proteins that are not enzymes, other quantification methods are required. Transport proteins can be assayed by their binding to the molecule they transport, and hormones and toxins by the biological effect they produce for example, growth hormones will stimulate the growth of certain cultured cells. Some structural proteins represent such a large fraction of a tissue mass that they can be readily extracted and purified without a functional assay. The approaches are as varied as the proteins themselves. 

Tl. Teh, L. C., Murphy, L. J., Huq, N. L., Surus, A. S., Friesen, H. G., etal., Methionine oxidation in human growth hormone and human chorionic somatomammotropin. Effects on receptor binding and biological activities. J. Biol. Chem. 262, 6472-6477 (1987). 

During the previous discussion of the biological effects of phytopolyphenols, the potential interactions of these compounds with growth receptors, cytokines, and hormones have been alluded to and indirectly signal transduction processes." The list of pertinent publications may be further expanded if we include the many reports of the inhibitory effects of phytopolyphenols with protein kinases or in tumor promotion/proliferation studies. 

In the past few years, considerable attention has been given to the presence of endocrine disrupting compounds (EDC) in the aquatic environment. EDC ate not defined by chemical nature but rather by their biological effect. The endocrine system is an intricate hormone system that regulates development, growth, reproduction, and behaviour [1-2]. The two relevant classes of compounds that can... 

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