Grooming

R. B., Quantitative Aspects of Chemical Pharmacology. Groom Helm, London, 1980. 

FDA s medical device regulations relating to adulteration and misbranding generally apply to devices intended for use on animals. These devices, however, are exempt from the 510(k) and PMA requirements. FDA has viewed animal grooming products as being outside of its purview. 

Hopkins, A. L., Groom, C. R., and Alex, A. (2004). Ligand efficiency A useful metric for lead selection. Drug Disc. Today 9 430-431. 

Hopkins AL, Groom CR (2002) The draggable genome. Nat Rev Drag Discov 1 727-730... 

Fhtients on bed rest require position changes and good skin care every 2 hours. The patient with an arthritis disorder may experience much pain or discomfort and may require assistance with activities, such as ambulating, eating, and grooming. Fhtients with osteoporosis may require a brace or corset when out of bed. 

Figure 12. A one hour dark image from LBNL p-channel CCD with several types of radiation events. Figure provided by D, Groom (LBNL),...

What if I am essentially grooming the mentee to take over my job ... 

LD50 values for the dermal route of exposure to methyl parathion have been established in acute studies for rats 67 mg/kg for males and females (Gaines 1960), 110 mg/kg for males, and 120 mg/kg for females (EPA 1978e). The LD50 in male mice exposed by dermal application of methyl parathion to their hind feet (rather than shaved backs) was 1,200 mg/kg (Skinner and Kilgore 1982a). The mice were muzzled to prevent oral exposure from grooming. 

In addition, amphetamine eauses hallueinations in humans similar to those in sehizophrenia and in rats it induees stereotyped behaviour (rearing, grooming and sniffing). This is dependent on the release of DA and bloeked by the neurolepties, whieh are DA antagonists. 

In this test, it is the interaction (sniffing, grooming, etc.) between two rats in a test arena that is scored. Social interaction is dependent on the familiarity of the animals with the test arena (social interaction is reduced in an unfamiliar arena) and the intensity of illumination (social interaction is reduced in bright light). The reduction in social... 

ATANASSOVA N, MCKINNELL C, TURNER K J, WALKER M, FISHER J S, MORLEY M, MILLAR M R, GROOME N p, SHARPE R M (2000) Comparative effects of neonatal exposure of male rats to potent and weak (environmental) estrogens on spermatogenesis at puberty and the relationship to adult testis size and fertility evidence for stimulatory effects of low estrogen lew eh,. Endocrinology. 141 3898-907. 

SAUNDERS P T, MILLAR M R, WILLIAMS K, MACPHERSON S, HARKISS D ANDERSON R A, ORR B, GROOME N p, scoBiE G, FRASER H M (2000) Differential expression of estrogen receptor alpha and beta and androgen recepto in the ovaries of marmosets and humans. Biol Reprod. 63 1088-95. 

A source of Aphrodisin which is present in an alternate emission vehicle is that of female saliva. Self-grooming spreads the signal on flank fur and passive or active deposition may then leave traces during contact with burrow walls. The sebaceous flank glands being inconspicuous (and dimorphic) in the female do not play a significant role in advertising her presence. 

Bocskei Z., Groom C., Flower D. Wright C.E., et al. (1992). Pheromone binding to two rodent urinary proteins revealed by X-ray crystallography. Nature 360, 186-188. 

Hopkins AL, Groom CR, Alex A (2004) Drug Discov Today 9 430... 

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