Pheromone-binding

Bacchini A., Gatetani E. and Cavaggioni A. (1992). Pheromone binding proteins of the mouse, Mus musculus. Experientia 48, 419-421. 

Bocskei Z., Groom C., Flower D. Wright C.E., et al. (1992). Pheromone binding to two rodent urinary proteins revealed by X-ray crystallography. Nature 360, 186-188. 

Briand L., Huet J., Perez V., Lenoir G., et al. (2000). Odorant and pheromone binding by aphrodisin, a hamster aphrodisiac protein. FEBS Letts 476, 179-185. 

Novotny, M.V. (2003) Pheromones, binding proteins and receptor responses in rodents. Biochem.Soc. Trans. 31, 117-122. 

Timm, D. E., Baker, L. J., Mueller, H., Zidek, L. and Novotny, M. V. (2001) Structural basis of pheromone binding to mouse major urinary protein (MUP-I). Protein Sci. 10, 997-1004. 

Fig. 2.6 Structures of the pheromone binding protein (form A) from the silk moth Bombyx mori [96] obtained in six iterative cycles of combined...

Insect OBPs are secretory proteins whose only posttranslational modification is the formation of three disulfide bridges [39,45] from six cysteine residues. That six cysteine residues are well conserved in OBPs from species of the same order is a hallmark of these proteins. The disulfide links of OBPs in a few species have been determined by analytical methods, first in the OBPs from B. mori [45,46]. As part of our attempt to get better insight into the structural biology of pheromone-binding proteins, we have determined the disulfide linkages... 

Unfortunately, the term OBP has been rather imprecisely used in the literature. It sometimes refers to the olfactory function played by proteins, such as the pheromone-binding protein from BmorPBP. However, quite often OBP... 

Recently, the structure of a pheromone-binding protein from the cockroach Leucophaea maderae, LmadPBP (Fig. 8b) has been solved by X-ray crystallography [58]. Despite the fact that LmadPBP and BmorPBP shared low amino acid identity (15% similarity 22%) (Fig. 9), the two proteins present similar folds. 

Fig. 9 Alignment of the amino acid sequences of pheromone-binding proteins from the silkworm moth B. mori and the cockroach L. maderae, BmorPBP and LmadPBP,respectively and a putative odorant-binding protein from D. melanogaster, LUSH. In LmadPBP and LUSH the N-terminal sequence of the mature proteins were predicted by cleaving signal peptides in silico [28,79], whereas in BmorPBP this was confirmed by the sequence of the isolated protein [38]...

Many pheromones travel from the tissue of their synthesis via the bloodstream to the surface of the body. They are also transported by larger molecules, notably proteins, both when being emitted by an odor donor ( outgoing ) and when being received in the olfactory mucosa of an addressee ( incoming ). In the saliva of the male pig, the pheromone-binding protein... 

There has been no research reported on the interaction of periplanones with pheromone-binding proteins or dendritic receptors. Nevertheless, two studies, one empirical and one theoretical, report on intrasensillar events in P. americana. Picim-bon and Leal (1999) determined the N-terminal amino acid sequences of two soluble proteins (putative odorant-binding proteins) that are specifically expressed in male antennae, and several other proteins that are expressed in antennae of both males... 

Our understanding of pheromone reception had undergone dramatic change just prior to 1987 with the proposal that Pheromone Binding Proteins (PBPs) and pheromone degrading enzymes transported and inactivated pheromonal signals... 

Bette S. Breer H. and Krieger J. (2002) Probing a pheromone binding protein of the silkmoth Antheraea polyphemus by endogenous tryptophan fluorescence. Insect Biochem. Mol. Biol. 32, 241-246. 

Maibeche-Coisne M., Sobrio F., Delaunay T., Lettere M., Dubroca J., Jacquin-Joly E. and Nagnan-LeMeillour P. (1997) Pheromone Binding Proteins of the moth Mamestra brassicae specificity of ligand binding. Insect Biochem. Mol. Biol. 27, 213-221. 

Picimbon J. F. and Gadenne C. (2002) Evolution and noctuid pheromone binding proteins identification of PBP in the black cutworm moth, Agrotis ipsilon. Insect Biochem. Molec. Biol. 32, 839-846. 

Plettner E., Lazar J., Prestwich E. G. and Prestwich G. D. (2000) Discrimination of pheromone enantiomers by two pheromone binding proteins from the gypsy moth Lymantria dispar. Biochemistry 39, 8953-8962. 

Sandler B. H., Nikonova L., Leal W. S. and Clardy J. (2000) Sexual attraction in the silkworm moth structure of the pheromone-binding-protein-bombykol complex. Chem. Biol. 7, 143-151. 

Vogt R. G., Koehne A. C., Dubnau J. T. and Prestwich G. D. (1989) Expression of pheromone binding proteins during antennal development in the gypsy moth Lymantria... 

Vogt R. G. and Riddiford L. M. (1981) Pheromone binding and inactivation by moth... 

Wojtasek H. and Leal W. S. (1999) Conformational change in the pheromone-binding protein from Bombyx mori induced by pH and by interaction with membranes. J. Biol. Chem. 274, 30950-30956. 

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