Grignard reagents, coupling

Biphenyl synthesis. In the presence of l,4-dichloro-2-butene, aryl Grignard reagents couple to form biphenyls. The coupling involves electron transfer to the... 

As shown in Scheme 78, with or without zinc chloride, benzylic Grignard reagents couple with vinyl bromide to form allylbenzene derivatives in high ee (188). This method has been used to prepare optically active allylsilanes in up to 95% ee. Vinylic bromides with E configurations lead to the E allylsilanes with high ee, and Z bromides lead to Z allylsilanes with lower ee. 

Grignard reagents couple with aryl hahdes without a palladium catalyst, by the benzyne mechanism, but an iron catalyzed coupling reaction was reported, " as... 

An allyl Grignard reagent coupled with epoxide at the less-substituted terminus of the Grignard in the presence of Cul, is exemplified in Eq. (30) [74,75]. This outcome is consistent with those appearing in Eqs. (9), (10), and (15). 

Di-Grignard reagents couple with m-dichlorobenzene to form m-cyclophanes in one step but in up to 20% yields depending on the chain lengths oxamethylene bridges can also be introduced (equations 95 and 96). ... 

Vinyl, 1-alkenyl and 2-alkenyl Grignard reagents couple with alkyl bromides or iodides in the presence of CuP -or AgNOa the configuration of the alkenyl Grignard reagent is essentially... 

Grignard (-like) reactions are emerging solid-phase reactions that have not yet been exhaustively studied. One is, therefore, tempted to conclude that the use of Grignard reactions in solid-phase chemistry is under-developed. A reason might be that the high reactivity of Grignard reagents coupled with the need for anhydrous conditions complicates with solid supported synthesis. 

Coupling. Grignard reagents couple with heteroaryl chlorides proceeds in the presence of MnCl2. ... 

Grignard reagents/nickel complei Coupling with neopentyl iodidt Grignard reagents couple with neop< Reaction with enol ethers, 2-S... 

Coupling with neopentyl iodides. On treatment with ZnCU and (dppf)NiCl2, Grignard reagents couple with neopentyl iodides. 

Pentacoordinate and metastable hexacoordinate phosphorus species have been detected and their evolution during the process of the reaction was studied using NMR spectroscopy. The diastereoselective outcome of the reaction between (44) and the bis-Grignard/mono-Grignard reagent couple has been explained via a pathway involving hexacoordination of the phosphorus as a key step. 

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