Grignard reagents coupling reaction

Nickel (II) Catalyzed Cross-Coupling with Grignard Reagents (Kumada Reaction) Pure AppJ. Chem. 1980, 52, 669 Bull Chern. Soc.Jpn. 1976, 49, 1958... 

CROSS-COUPLING OF ARYLCHLORIDES WITH ARYL GRIGNARD REAGENTS (KUMADA REACTION)... 

Huang, J. Nolan, S. P. Efficient cross-coupling of aryl chlorides with aryl Grignard reagents (Kumada reaction) mediated by a Pd/imidazolium chloride system./. Am. 

Grignard reagents couple with aryl hahdes without a palladium catalyst, by the benzyne mechanism, but an iron catalyzed coupling reaction was reported, " as... 

Huang, J., Nolan, S. P. Efficient Cross-Coupling of Aryl Chlorides with Aryl Grignard Reagents (Kumada Reaction) Mediated by a Palladium/lmidazolium Chloride System. J. Am. Chem. Soc. 1999, 121,9889-9890. 

Grignard (-like) reactions are emerging solid-phase reactions that have not yet been exhaustively studied. One is, therefore, tempted to conclude that the use of Grignard reactions in solid-phase chemistry is under-developed. A reason might be that the high reactivity of Grignard reagents coupled with the need for anhydrous conditions complicates with solid supported synthesis. 

Grignard reagents/nickel complei Coupling with neopentyl iodidt Grignard reagents couple with neop< Reaction with enol ethers, 2-S... 

Pentacoordinate and metastable hexacoordinate phosphorus species have been detected and their evolution during the process of the reaction was studied using NMR spectroscopy. The diastereoselective outcome of the reaction between (44) and the bis-Grignard/mono-Grignard reagent couple has been explained via a pathway involving hexacoordination of the phosphorus as a key step. 

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