Granulation fluidized-layer

Liske T, Mobus W. The manufacture and comparative aspects of fluidized layer spray granulation. Drugs made in Germany 1968 XI 182-189. 

A known method of continuous granulation in a boiling (fluidized) layer and a device therefore are disclosed in a Japanese Patent22). 

In the event of continuous and intermittent fluidized-layer granulators3l), the source powder is mixed due to creation of a boiling (fluidized) layer in the air flow, the powder being sprinkled with a suitable liquid until granules are formed. 

One major objective of this feasibility was to assess the potential of acoustic chemometrics to monitor the general process state of the granulation reactor in order to give reliable early warning if a critical situation occurs in the bed. Critical situations in the fluidized bed are often a result of lump formation and/or layering on the perforated bottom plate of the reactor (see Figure 9.5). 

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