Granulation layering

Fig. 2. Changes in immunoreactivity for the a4 subunit of the GABAa-R in the rat hippocampus during pregnancy and after delivery. (A, B) Representative immunohistochemical images of the distribution of the a4 subunit in the dentate gyrus (A) and in the CA1 region (B) in hippocampal sections from rats in estrus (E) at day 15 (P15), 19 (P19), or 21 (P21) of pregnancy or at 2 (pp2) or 7 (pp7) days after delivery, (m) Molecular and (g) granule layer of the dentate gyrus and (o) sti atum...

Figure 6.9 Prevention of flame transmission through a granule layer above a low energy ignition source (=s10J) [2], Safe granule layer height hs versus granule diameter d.

The M/TC layer was measured in the same manner, using the Goa-stained slides to discern it (Figure 2). The granule layer, visible in Nissl stained sections, could not be reliably measured because it merges with the granule cell layer of the MOB. 

THERMOPHYSICAL CHARACTERISTICS OF GRANULE LAYER OF FIBER-FORMING POLYMERS STUDIED IN A BICALORIMETER. 

Fig. 12. The relation between field epsp amplitude and perforant path stimulus intensity in young ( ) and old (O) rats is shown for the in vivo (A) and in vitro (D) preparations. For comparison, stimulus intensity is expressed as the product of current and duration since these two parameters were varied differently in the two preparations. For the in vivo experiment, response wave forms were averaged across animals within the young (B) and old (C) groups. Superimposed traces at the various stimulus levels recorded simultaneously from the granule layer (E) and the molecular layer (F) are shown from a single slice preparation. The dashed lines in B, C, and E indicate the time of measurement of the field epsp (2 msec after stimulus onset). The sharp negative deflections in B, C, and E are population spikes (asterisks), whereas the early negative deflection in F represents the presynaptic fiber response (arrow). (From Barnes and McNaughton, 1980.)...

Fig. 152. Microglial cell infiltration in the granule layer of the cerebellum (block 4766) of a 221 g female rat (N0.668) medicated with 5,000 ppm molsidomine added to the food (powdered Altromin R) from July 17/18, 1978 to November 30, 1978. After discontinuation of the medication for 7 weeks, under pentobarbital anaesthesia (30 mg/kg), the animal was perfused from the abdominal aorta with 2.5 % glutaraldehyde in 0.1 M sodium cacodylate buffer (pH 7.4). Postfixation with 1 % osmium tetroxide in sodium cacodylate buffer. Embedded in Epon 812 and sectioned at 50 nm. Lead citrate and uranyl acetate. Film 182/79...

Ascorbic acid having the unique property of reducing an acidified solution of silver nitrate almost instantly (Gomori 1952, p.90), in the granule layer of the human cerebellum can only be detected in a few glial cells (Clara 1942, 1953). 

Fluid bed granulation/layering/film coating Removal of solvent in various conventional pharmaceutical equipments... 

The most commonly used solvents for MBP are DMA, DMF, DMSO, and NMP. Other solvents such as alcohols and acetone may also be used, but they are less favored for MBP because if there is adequate solubility in these solvent, other means of ASD manufacture such as spray drying or fluid bed granulation/layering may be feasible. List of solvents with their relevant properties is summarized in Table 10.3. 

Fig. 7.1 Basic principles of spray fluidized bed processes (a) agglomeration, (b) granulation (layering), (c) coating.

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