Granulators fluidized

Liquid and solids Size enlargement High shear mixer granulator, fluidized granulator (bubbling bed, spouted bed)... 

Reduce the mobility of the API, by mechanically binding the API to the formulation excipients Quality Granulation fluidization and sifting segregation potential Tablet content uniformity... 

Spray onto dispersed powder (cf. powder clustering, agitation methods above) Atomized liquid feed is sprayed into circulating dispersion of already-dried particles. Hot gases maintain dispersion. Spray granulation, spouted and fluidized bed granulation Fluidized and spouted beds, Wurster apparatus... 

Though it has been practiced for many years and therefore may be perceived as an old-fashioned process, it must be borne in mind that the wet granulation process has itself undergone a transformation in recent decades. High-speed mixer-granulators, fluidized bed... 

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