Gpl20 coreceptors

Vives RR, Imberty A, Sattentau QJ, Lortat-Jacob H. Heparan sulfate targets the HIV-1 envelope glycoprotein gpl20 coreceptor binding site. J Biol Chem 2005 280 21353-21357. 

Deng H, Liu R, Ellmeier W, Choe S, Unutmaz D, Burkhart M, Di Marzio P, Marmon S, Sutton RE, Hill CM, Davis CB, Peiper SC, Schall TJ, Littman DR, Landau NR (1996) Identification of a major co-receptor for primary isolates of HIV-1. Nature 381 661-666 Derdeyn CA, Decker JM, Sfakianos JN, Wu X, O Brien WA, Ratner L, Kappes JC, Shaw GM, Hunter E (2000) Sensitivity of human immunodeficiency virus type 1 to the fusion inhibitor T-20 is modulated by coreceptor specificity defined by the V3 loop of gpl20. J Virol 74 8358-8367... 

Yuan W, Craig S, Si Z, Farzan M, Sodroski J (2004) CD4-induced T-20 binding to human immunodeficiency virus type 1 gpl20 blocks interaction with the CXCR4 coreceptor, J Virol 78 5448-5457... 

Understanding the nature of the domains or elements on the chemokine receptor coreceptors is also of significant importance, especially with regard to the development of coreceptor-blocking therapeutics. HIV-1 gpl20 interacts with multiple extracellular domains of the chemokine receptors to mediate binding, and the N-terminus and extracellular loop (ECL) number 2 of CCR5... 

Platt EJ, Kuhmann SE, Rose PP, Rabat D. Adaptive mutations in the V3 loop of gpl20 enhance fusogenicity of human immunodeficiency virus type 1 and enable use of a CCR5 coreceptor that lacks the amino-terminal sulfated region. J Virol 2001 75(24) 12266-12278. 

It has been reported that the N-terminal CCR5, the coreceptor for binding of CD4-gpl20 complex, is tyrosine rich and the tyrosines are posttranslationally converted to sulfated tyrosines (54-56). The NMR, X-ray, and docking-based structure of the... 

Dey B, Lerner DL, Lusso P et al (2000) Multiple antiviral activities of cyanovirin-N blocking of human immunodeficiency virus type 1 gpl20 interaction with CD4 and coreceptor and inhibition of diverse enveloped viruses. J Virol 74 4562 569... 

Like ASLV, HIV has a multistep mechanism for activation of membrane fusion. However, low pH is not required for HIV entry, and the virus instead uses a series of distinct interactions with components of the target membrane (reviewed in Dorns and Trono, 2000). The first interaction is with the CD4 protein. This binding event enables a subsequent contact between the HIV SU subunit gpl20 and a molecule of the chemokine receptor family (reviewed in Choe et al, 1998). It is this second interaction with molecules termed coreceptors that activates the membrane fusion potential of the TM subunit gp41 (reviewed in Berger et al, 1999). 

Neurath AR, Strick N, Li YY, Debnath AK. Cellulose acetate phthalate, a common pharmaceutical excipient, inactivates HIV-1 and blocks the coreceptor binding site on the virus envelope glycoprotein gpl20. BMC Infect Dis 2001 1(1) 17. 

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