Good leads

While an analysis of individual components in morama beans (above) can give a good lead to their possible beneficial and negative effects, it is the sum total, antagonistic or synergistic effects of the various component combinations which determine their overall effect on health. It is the high content of amino acids, and some fatty acids, complemented with minor... 

To summarise the arguments, the majority of NPs foimd in plants and microbes are unlikely to possess potent biological activity and even less likely to contain specific, potent biological activity that could be usefully exploited for pharmaceutical use. Furthermore, even when a naturally derived chemical is found to give a good lead, the chemical complexity so characteristic of NPs may make commercial production expensive or impossible. It is surely significant that culturable microbes have been so important as producers of NPs of pharmaceutical value to humans because they can be selected to overproduce complex molecules that humans would find impossible to make. 

Pentane isomerization was carried out on a much smaller scale. Isopentane, because of its high octane number and good lead response, was blended directly into aviation gasoline. It also served to increase the volatility of blends containing such high-boiling components as alkylate. 

A continuing collection of new and preferably unique plants at a rate sufficient to generate several good leads per year. 

Any unevenness in the equipment across the width of the goods leads to unlevel dyeings. 

In our exploratory studies, we have now found good leads for yielding as much as 75-80% C2 C4 olefin product, which in turn can be converted to good quality distillate.( 5,6) We can now consider the co-production of gasoline and distillate from methanol as shown in Figure 15. Engineering and development studies are in the initial phases of evaluating such concepts. 

One strategy to address these problems is to develop antiretroviral drugs with targets other than reverse transcriptase and protease. In the collaboration of our laboratories at the University of North Carolina and Panacos Pharmaceuticals, we have taken advantage of the huge molecular diversity found in natural products. Plants are a major source of biologically active compounds and can provide good leads that are structurally unique and/or have new mechanisms of action. 

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