Gold computed tomography

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C. Hall, L.A. Harsan, M. Stebel, D. Barbetta, G. Tromba, E. ArfelU, In vivo visualization of gold-loaded cells in mice using x-ray computed tomography, Nanomedicine 9 (2) (2013) 284—292. 

In X-ray computed tomography (CT) the radioopacity of metallic nanoparticles (for example bismuth and gold ) have been used to generate localized contrast in the imaging of blood vasculature, liver and lymph nodes. 

The particles were shown to be multimodal in their capacity to provide both CT and MR contrast. Synchrotron radiation computed tomography (SRCT) phantom imaging was obtained at a gold concentration of 1.4mg mLr which is lower than the detection threshold of a conventional CT scanner. In vivo SRCT images of mice and rats were obtained at a concentration of 10 mg mL7 which corresponds to a 5mM Gd. MR images were enhanced by the presence of the particles. Postmortem ICP mass spectrometry showed the particles to distribute mostly to the kidneys of the animals, where they were readily cleared in the urine. Interestingly,... 

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Finally, novel multimodal imaging nanoplatforms have also been developed these consist of mimicking nanoparticles with multimodal HDLs into which gold, iron oxide, or quantum dot nanocrystals have been incorporated for computed tomography, MR, and fluorescence imaging. 

Peng C, et al. PILGylated dendrimer-entrapped gold nanoparticles for in vivo blood pool and tumor imaging by computed tomography. Biomaterials 2012 33 1107-19. 

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Peng C, Li K, Cao X, Xiao T, Hou W, Zheng L, Guo R, Shen M, Zhang G, Shi X (2012) Facile formation of dendrimer-stabUized gold nanoparticles modified with diatrizoic acid for enhanced computed tomography imaging applications. Nanoscale 4 6768... 

Kim, D Park, S., Lee, J.H., Jeong, Y.Y. and)on, S. (2007) Antibiofouling polymer-coated gold nanopartides as a contrast agent for in vivo X-ray computed tomography imaging. Journal of the American Chemical Sodety, 129, 7661-5. 

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