Goals of the Book

Depending on the primary aim, two main areas in preparative chromatography are distinguished. It is possible to use preparative chromatography either to prepare the small amounts of purified products required for e.g., their structural identification, or to produce large amounts of an intermediate or a final product for commercialization. 

In the second area, a purified compound is needed to obtain a final product, and the cost of the production of the compoxmd is an important cost factor that will have to be minimized. The production will last a significant period of time, whether it is continuous or by batches rrm periodically, and the operation is relatively routine. The cost components, equipment, solvent, packing material, crude feed, and downstream processing become prominent and must be taken into account together. Then significant investment in the design of the separation process is required for a careful optimization of the experimental conditions. Optimization procedures are discussed in Chapter 18. 

The fundamental problems of nonlinear chromatography and the theory of preparative chromatography have been the topic of intense activity by chromatogra-phers and chemical engineers. Each community has largely overlooked the activities, as well as the preoccupations and viewpoints, of the other one. Furthermore, this activity did not start abruptly and is not entirely finished. Theoretical problems in nonlinear chromatography have been discussed in the literature for more than 50 years and some are still today. Some of these works have been quite influential in some circles, while they were completely ignored in others. 

Preparative chromatography will continue to play a role of major importance as a separation process in the pharmaceutical and biotechnological industries in the next quarter of a century. A number of different processes are already used. Some of them will imdergo considerable improvement. A few others will be invented or developed. There is presently no simple way to have easy access to the 

We have attempted to present here, in a rather condensed form, a vievc of the present status of the fxmdamentals of preparative and nonlinear chromatography. The fundamental problems and the various models used to model chromatography are discussed first (Chapter 2). As the thermodynamics of phase equilibrium is central to the separation process, whatever model is used, we devote two chapters to the discussion of equilibrium isotherms, for single components (Chapter 3) and mixtures (Chapter 4). A chapter on the problems of dispersion, mass transfer and flow rate in chromatography (Chapter 5) completes the fundamental bases needed for the thorough discussion of preparative chromatography. 

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The (Impossible ) Goals of the Book A Short Guide to the Book... 

The third and final goal of the book is to provide tools that can be used to manage and improve performance of a supply chain. These tools... 

The subject of this book is of an interdisciplinary nature. The theme is at a junction of physics, chemistry, materials science, computer simulation, physical metallurgy, and crystallography. The goal of the book is particularly to demonstrate how the properties of materials can be derived and predicted proceeding from the quantum properties of their structural elements. We would like to show the methods of the model construction and simulation. 

A third goal of the book is to bring an appropriate historical perspective to the material. American students, more so than those of other nations, seem to lack an appreciation of the centuries of human endeavor that have led to our present... 

Abstract A brief introduction to dimensionality reduction and manifold learning is provided and supported by a visual example. The goals of the book and its place in the literature is given, while the chapter is concluded by an outline of the remainder of the book. 

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