Glycolate spacer

H. Sashiwa, Y. Shigemasa, and R. Roy, Chemical modification of chitosan. 3. Hyperbranched chitosan-sialic acid dendrimer hybrid with tetraethylene glycol spacer, Macromolecules, 33 (2000) 6913-6915. 

N. Benfaremo, D.J. Sandman, S. Tripathy, J. Kumar, K. Yang, M.F. Rubner, and C. Lyons, Synthesis and characterization of luminescent polymers of distyrylbenzenes with oligo(ethylene glycol) spacers, Macromolecules, 31 3595-3599, 1998. 

Y. F. Ng, J. C. Meillon, T. Ryan, A. P. Dominey, A. P. Davis and J. . M. Sanders, Gel-phase MAS NMR spectroscopy of a polymer-supported pseudorotaxane and rotaxane Receptor binding to an inert polyethylene glycol spacer, Angewandte Chemie-International Edition, 2001, 40, 1757-1760. 

Fullerene stoppers have also been introduced in rotaxanes as a way to probe the motion of the ring thanks to their well-defined photophysical and electrochemical properties.54 In the rotaxane shown in Scheme 9.12, the hydrogen bonding station (a glycylglycine template) was placed far away from the fullerene by a triethylene glycol spacer.55... 

The nucleation of parallel (3-sheet structure via metal ion chelation in aqueous solution was investigated by incorporating an ethylene glycol spacer between a dibenzofuran-4,6-dipro-panoic acid template and the two peptide strands (Scheme 6).[7 The flexibility of the ethylene glycol spacer allows the peptide to sample a variety of largely unordered conformations in the absence of metal ions. Upon binding of palladium(II), nickel(II), or copper(II) ions, the peptidomimetic adopts a well-defined (3-sheet conformation as discerned from biophysical and spectroscopic studies (i.e., CD, IR absorption, and H NMR spectrometry).17 The synthesis of the dibenzofuran-4,6-dipropanoic acid template was discussed... 

Scheme 6 Incorporation of an Ethylene Glycol Spacer Between the Template and the Peptide Strands 1...

Both end groups at the spacer molecule, OH and especially NH2, are important for further biochemical synthesis. As follows from XPS measurements, in all cases only 2% Br was not consumed and remained at the PP surface. It was assumed that either steric problems played a role or these bromine groups were not situated directly at the surface. For all glycolate spacers a functionalization density of about 5 spacer-bonded OH groups per 100 C was measured. Additionally, two directly at the surface bonded (without spacer) OH groups per 100 C atoms were also detected. 4-5 NH2 groups/100 C were found using... 

Xia Y, Wu BA, Li SG et al (2010) Anion binding of a bis(pyridylcarbamate) receptor bearing a diethylene glycol spacer. Supramol Chem 22 318-324... 

Surface plastnon resonance Association constant Dissociation constant Hexaethylene glycol spacer Sambucus nigra agglutinin High-mobility-group transcriptional factor Soluble green fluorescent protein Calmodulin... 

Gruber HJ, Marek M, Schindler H, Kaiser K. Biotin-fluorophore conjugates with poly(ethylene glycol) spacers retain intense fluorescence after binding to avidin and streptavidin. Bioconj. Chem. 1997 8 552-559. 

Figure 9 Structure of the GPI anchor found in eukaryotes (phosphoethanolamine linker shown in red, phospholipid tail shown in black). Paulick and coworkers examined several truncated forms of the GPI anchor to examine the functional significance of the core glycan structure. These include structures replacing three (cyan), four (orange and cyan), or five (green, orange, and cyan) of the sugars in the conserved pentasaccharide structure with appropriate ethylene glycol spacers.

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