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Polyethylene glycol, spacer molecules

The influence of the structure of the main chain on the chymotrypsin catalyzed release of p-nitroaniline is shown in Fig. 15. Oligopeptide p-nitroanili-des were attached to HPMA copolymers (as side-chains) and to polyethylene glycol (end-point attachment). From the values of kcat/KM it is evident that all oligopeptide p-nitroanilides attached to PEG were cleaved faster than those attached to HPMA copolymers. It appeared that the PEG substrates fit better into the active site of chymotrypsin due to the linearity and flexibility of the PEG molecule, and the type of spacer attachments [255]. [Pg.99]

The basic function of spacer is to distance the tethered molecules, mostly bioactive compounds, from the surface of the solid support to minimize the steric hindrance and maximize the functions of linked molecules. Polyethylene glycol (PEG) is a neutral polyether which is soluble in water as well as most organic solvents. PEG is unusually effective in excluding other... [Pg.66]

See other pages where Polyethylene glycol, spacer molecules is mentioned: [Pg.306]    [Pg.45]    [Pg.170]    [Pg.230]    [Pg.976]    [Pg.100]    [Pg.175]    [Pg.139]    [Pg.46]    [Pg.553]    [Pg.47]    [Pg.233]    [Pg.155]    [Pg.167]    [Pg.1163]    [Pg.189]    [Pg.161]    [Pg.71]    [Pg.81]    [Pg.83]    [Pg.413]    [Pg.10]    [Pg.333]    [Pg.31]   
See also in sourсe #XX -- [ Pg.413 ]



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