Glycogen transferase

Figure 21.16. Structure of Glycogen Transferase. A conserved aspartate residue forms a covalent intermediate with a chain of glucose molecules.

BISHOP, J. S. and LARNER, J. (1967) Rapid activation-inactivation of liver uridine diphosphate glucose-glycogen transferase and phosphorylase by insulin and glucagon in vivo. J. Biol. Chem., 242, 1354 ... 

Pyridoxamine phosphate serves as a coenzyme of transaminases, e.g., lysyl oxidase (collagen biosynthesis), serine hydroxymethyl transferase (Cl-metabolism), S-aminolevulinate synthase (porphyrin biosynthesis), glycogen phosphoiylase (mobilization of glycogen), aspartate aminotransferase (transamination), alanine aminotransferase (transamination), kynureninase (biosynthesis of niacin), glutamate decarboxylase (biosynthesis of GABA), tyrosine decarboxylase (biosynthesis of tyramine), serine dehydratase ((3-elimination), cystathionine 3-synthase (metabolism of methionine), and cystathionine y-lyase (y-elimination). 

Lamarre, M. and Desrosiers, R. R. (2008). Up-regulation of protein L-isoaspartyl methyl-transferase expression by lithium is mediated by glycogen synthase kinase-3 inactivation and beta-catenin stabilization. Neuropharmacology 55, 669-676. 

Diabetes - insulin dependent Methyl malonic, propionic or isovaleric acidaemias Pyruvate carboxylase and multiple carboxylase deficiency Gluconeogenesis enzyme deficiency glucose-6-phosphatase, fructose-1,6-diphosphatase or abnormality of glycogen synthesis (glycogen synthase) Ketolysis defects Succinyl coenzyme A 3-keto acid transferase ACAC coenzyme A thiolase... 

Allosteric Enzymes Typically Exhibit a Sigmoidal Dependence on Substrate Concentration The Symmetry Model Provides a Useful Framework for Relating Conformational Transitions to Allosteric Activation or Inhibition Phosphofructokinase Allosteric Control of Glycolysis Is Consistent with the Symmetry Model Aspartate Carbamoyl Transferase Allosteric Control of Pyrimidine Biosynthesis Glycogen Phosphorylase Combined Control by Allosteric Effectors and Phosphorylation... 

Biosynthetic processes Elongation of RNA or DNA chains Other synthetic routes RNA polymerase I DNA polymerase Poly(ADP-ribose)polymerase Carbamoyl phosphate synthetase Anthranilate synthase-phosphoribosyl transferase Glycogen synthetase Methionyl-tRNA synthetase ATP phosphoribosyl transferase Zn2+... 

Figure 5. The hydrolysis of glycogen phosphorylase limit dextrin by the purified glucosidase-transferase as a function of pH in various buffers. Adapted from...

Other investigators have also differentiated the two activities. The apparent absence of transferase but not glucosidase activity has been proposed as a subclass of type III glycogen storage disease (37). Exposure of the enzyme to guanidine inhibited glucosidase activity on "fast B5" to a greater extent than the combined activity on "63-a-maltotriosylmaltotetraose"... 

Figure 11. Double reciprocal plot of the action of the glucosidase-transferase on glycogen phosphorylase limit dextrin in the presence ofTris(ll).

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