Glyceryl trinitrate Glycol

The decomposition rates of several glycol nitrates and glyceryl trinitrate are greatly enhanced by the presence of transition metal oxides or chelates. 

Know the meaning of chromic anhydride, PCC, aldehyde, ketone, carboxylic acid, glycol, glycerol, sorbitol, glyceryl trinitrate (nitroglycerine), quinone, antioxidant. 

Propylene glycol causes acute hemolysis with raised lactate dehydrogenase activity, and raised bilirubin and plasma hemoglobin concentrations after use of a stock solution during intravenous administration of glyceryl trinitrate (11). 

Resistance to heparin has been observed in patients in coronary care units receiving intravenous glyceryl trinitrate. Although this has been imputed to propylene glycol in glyceryl trinitrate formulations (113), resistance has also been described with propylene glycol-free... 

Intracranial hypertension associated with glyceryl trinitrate has been reported and attributed to cerebral vasodilatation (47). However, it may occasionally be a consequence of hyperosmolality, hemolysis, and lactic acidosis caused by the excipient ethylene glycol used with intravenous isosorbide dinitrate. The risk of this may be greatest in patients with renal impairment (48). 

Glyceryl trinitrate, a volatile dmg with a chloroform/water partition coefficient of 109, diffuses from simple tablet bases into the walls of plastic bottles and into plastic liners used in packaging tablets. This partitioning can be prevented if there is included in the tablet formulation an agent (such as polyoxyethylene glycol) which complexes with the dmg substance, thereby increasing its affinity for the tablet phase - in other words, reducing its... 

Theoretically speaking, nitroglycerin can mix with nitric acid ester, ethylene glycol dinitrate, diethylene glycol dinitrate, glyceryl dinitrate, glycerol trinitrate isobutyl nitro, azido nitrate, nitric acid hydroxyl ester at any ratio, respectively. The chemical equation of nitroglycerine can be described as follows ... 

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