Glyceryl trinitrate sublingual administration

After sublingual administration of 0.3 mg to 1 subject, a blood concentration of about 0.001 ag/ml was attained in 3 minutes following an oral dose of 6.5 mg or application of an ointment containing 16 mg of glyceryl trinitrate to the same subject, peak blood concentrations of about... 

Two sites within the buccal cavity have been used for drug administration. Using the sublingual route, as for glyceryl trinitrate (GTN), the medicament is placed under the tongue, usually in the form of a... 

In a 61-year-old man topical endobronchial administration of adrenaline (3 ml of a 1 10 000 solution) resulted in chest pain, ST segment elevation, and ventricular extra beats the chest pain with sublingual glyceryl trinitrate resolved, as did the ST segment abnormalities [63" ]. Cardiac catheterization showed that he had mild coronary artery disease. 

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