Glutathione S-transferase induction

AO/FRS - scavenges OH, HOC1 i Fe(II)- Cu(II)-dependent lipid OH generation from H202, FA oxidation protein oxidation AO (per glutathione-S-transferase induction) AO/FRS - scavenges 02-, NOV [keeps thiols reduced in cytosol]... 

WALLiGM A, KINGSTON s, STAACK R and JEFFEREY E H (1998) Induction of rat pancreatic glutathione S-transferase and qitinone reductase activities by a mixture of glucosinolate breakdown derivatives foimd in Brussels sprouts . Food Chem Toxicol, 36 365-73. 

It is possible that dietary flavonoids participate in the regulation of cellular function independent of their antioxidant properties. Other non-antioxidant direct effects reported include inhibition of prooxidant enzymes (xanthine oxidase, NAD(P)H oxidase, lipoxygenases), induction of antioxidant enzymes (superoxide dismutase, gluthathione peroxidase, glutathione S-transferase), and inhibition of redox-sensitive transcription factors. 

Yu SJ (1982) Host plant induction of glutathione S-transferases in the fall armyworm. Pestic Biochem Physiol 19 101-106... 

Landi, S., Ponzanelli, I., Hirvonen, A., Norppa, H. Barale, R. (1996b) Repeated analysis of sister chromatid exchange induction by diepoxybutane in cultured human lymphocytes effect of glutathione S-transferase Tl and Ml genotype. Mutat. Res., 351, 79-85... 

Cmarik, J.L., Inskeep, P.B., Meredith, M.J., Meyer, D.J., Ketterer, B. Guengerich, F.P. (1990) Selectivity of rat and human glutathione S-transferases in activation of ethylene dibromide by glutathione conjugation and DNA binding and induction of unscheduled DNA synthesis in human hepatocytes. Cancer Res., 50, 2747-2752... 

Kang KW, Choi SH, Kim SG. 2002. Peroxynitrite activates NF-E2-related factor 2/ antioxidant response element through the pathway of phosphatidylinositol 3-kinase The role of nitric oxide synthase in rat glutathione S-transferase A2 induction. Nitric Oxide 7 244-253. 

Duvoix A, Morceau F, Delhalle S, Schmitz M, Schnekenburger M, Galteau MM, Dicato M, Diederich M. 2003. Induction of apoptosis by curcumin Mediation by glutathione S-transferase PI—1 inhibition. Biochem Pharmacol 66 1475-1483. 

Susan M, Rao MN. 1992. Induction of glutathione S-transferase activity by curcumin in mice. Arzneimittelforschung 42 962-964. 

Similarly, it has been shown that consumption of cruciferous vegetables is associated with a lower incidence of cancers. Induction of phase II enzymes such as the glutathione S-transferase (GST) and quinone reductase (QR) have been demonstrated in broccoli, cabbage, and brussel sprouts. Many natural isothiocyanates derived from cruciferous vegetables and some fruits have been shown to cause induction of phase II enzymes in cultured cells and rodents. 

Snyder M. J., Walding J. K. and Feyereisen R. (1995) Glutathione S-transferases from larval Manduca sexta midgut sequence of two cDNAs and enzyme induction. Insect Biochem. Mol. Biol. 25, 455 465. 

Sano M, Hagiwara A, Tamano S, et al. 1999. Dose-dependent induction of carcinomas and glutathione s-transferase placental form negative eosinphilic foci in the rat liver by di(2-ethylhexyl) phthalate after diethylnitrosamineinitiation. J Toxicol Sci24(3) 177-186. 

Cytosol easy to use, cheap addition of cofactors (simple mixtures), Only not membrane-bound metabolizing enzymes such as alcohol dehydrogenases, sulfotransferases, glutathione S transferase, N-acetyl transferases partial metabolic profile, induction not modeled... 

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