Glutamic dehydrogenase and

Energy-linked transhydrogenase, a protein in the inner mitochondrial membrane, couples the passage of protons down the electrochemical gradient from outside to inside the mitochondrion with the transfer of H from intramitochondrial NADH to NADPH for intramitochondrial enzymes such as glutamate dehydrogenase and hydroxylases involved in steroid synthesis. 

McKenna,M. C.,Stevenson,J. H.,Huang,X. etal. Differential distribution of the enzymes glutamate dehydrogenase and aspartate aminotransferase in cortical synaptic mitochondria contributes to metabolic compartmentation in cortical synaptic terminals. Neurochem. Int. 37 229-241, 2000. 

Figure 8.6 The three dehydrogenase (oxidase) reactions in amino acid degradation. The enzymes are D-amino acid oxidase, glutamate dehydrogenase and proline oxidase (dehydrogenase). Biochemical details are given in Appendix 8.4.

Figure 8.25 Excess ammonia in the muscle is used to form alanine. Ammonia is released from several reactions and is incorporated into alanine via glutamate dehydrogenase and transamination. OG - oxoglutarate. Alanine is released into the blood from volece it is removed by the liver.

Reactions (ii) and (iii) are catalysed by glutamate dehydrogenase and aspartate aminotransferase, respectively. 

The reactions of Eq. 15-19 occur nonenzymatically only under the influence of strong base but dehydrogenases often catalyze similar condensations relatively rapidly and reversibly. Pyruvate inhibits lactate dehydrogenase, 2-oxoglutarate inhibits glutamate dehydrogenase, and ketones inhibit a short-chain alcohol dehydrogenase in this manner.133,693... 

Glutamate Dehydrogenase and Glutamate 1397 1. Biosynthetic Pathways from Serine... 

What is the function of NADPH in the reactions catalyzed by glutamate dehydrogenase and glutamate synthase ... 

Fig. 3. Assimilation of ammonia by (a) glutamate dehydrogenase and (b) glutamine synthetase.

In peripheral tissues, two enzymes, namely glutamate dehydrogenase and glutamine synthetase, are important in the removal of reduced nitrogen, and particularly so in the brain, which is highly susceptible to free ammonia. 

The effect of alcohol abuse, one of the most common aggravating factors in vitamin A toxicity, has been elucidated. Vitamin A toxicity was potentiated in patients who took 10 000 lU/day for sexual dysfunction, and this effect was attributed to excess alcohol consumption (95). In animals, potentiation of vitamin A toxicity by ethanol resulted in striking hepatic inflammation and necrosis accompanied by a rise in serum glutamate dehydrogenase and aspartate transaminase (96). 

X.L., and Li, C.Z. (2007) Amperometric glutamate biosensor based on selfassembling glutamate dehydrogenase and dendrimer-encapsulated platinum nanoparticles onto carbon nanombes. Talanta, 73, 438 43. 

Glutamate is derived by transamination of a-keto-glutarate produced in the TCA cycle from citrate via oxaloacetate and acetyl-CoA (Chapter 13). All of the amino acids can produce acetyl-CoA. All except leucine and lysine (which are oxidized solely to acetyl-CoA) can be used in net synthesis of a-ketoglutarate to enhance glutamate synthesis. Ammonia is generated in glutamate dehydrogenase and AMP deaminase reactions (Chapter 21). 

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