Glucose with hemoglobin

A 61-year-old man with a 7-year history of diabetes, well-controlled with diet and acarbose, developed prostate cancer and was given leuprorelin acetate and flutamide. After the second injection of leuprorelin his fasting glucose and hemoglobin Alc concentrations were markedly raised (23 mmol/1 and 11% respectively). 

Hyperinsulinemia is common in recipients of somatropin, but the long-term effects are controversial. This issue is becoming increasingly important as more adult patients are treated and the duration of therapy is extended. Growth hormone deficiency is itself associated with insulin resistance (36). Plasma concentrations of glucose and hemoglobin Aic increase, especially in the first 6-12... 

Telltale adduct. Glucose reacts slowly with hemoglobin and other proteins to form covalent compounds. Why is glucose reactive What is the nature of the adduct formed ... 

Sowers, J. R., Tuck, M. L., and Sowers, D. K., Plasma antithrombin III and thrombin generation time correlation with hemoglobin Ai and fasting serum glucose in young diabetic women. Diabetes Care 3, 655-658 (1980). 

Consumption of cranberry juice (100-150 ml daily) for 7 weeks was reported to interfere with urinary dipstick tests for glucose and hemoglobin (Kilbourn 1987). 

KUbourti, J.R 1987. Interference with dipstick tests for glucose and hemoglobin in urine by ascorbic acid in cranberry juice. Clin. Chem. 33(7) 1297. 

Many clinical chemistry assays are based on UVAfIS spectrophotometry, often by reaction of the chemical of interest, snch as glucose, with an enzyme and dye to create a colored complex. A novel method for determining the age of dried bloodstains at a crime scene has been developed by researchers at the National Center for Forensic Science at the University of Central Horida using the Implen NanoPhotometer Pearl (Hanson and Ballantyne). The researchers discovered a previously unidentified hypsochromic shift (a blue shift to shorter wavelengths) in the Soret band of hemoglobin =412... 

Dailey G (2007) Assessing glycemic control with self-monitoring of blood glucose and hemoglobin A(lc) measurements. Mayo Clin Proc 82(2) 229-236... 

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