Glucose Glutl

Fig. 2.1 Glucose and ketone body transporters with hypoxia. The relative increase in moncar-boxylate (MCTl) and glucose (GLUTl) transporters at the blood—brain barrier following 10% (0.5 atm. oxygen) exposure of hypobaric-hypoxia. Quantification of cerebral capillary density, as measured by GLUTl immunostaining, and MCTl immunoreactivities (number of counts per mm ) showed about a 30% upregulation of MCT 1 and GLUTl transporters with 3 week hypoxic exposure in rat brain. P < 0.05, hypoxic vs. normoxic...

GLUTl Most tissues (brain, red ceUs) 1 mM Basal uptake of glucose... 

Gottschalk, 1., Li, Y. M., Lundahl, P. Chromatography on cells analyses of solute interactions with the glucose transporter Glutl in human red cells adsorbed on lectin-gel beads. 

Uniport is when one substance is transported in a single direction, eg, the GLUTl glucose transporter of the RBC. 

Glucose uptake is mediated by the glucose transporters GLUTl or GLUT4... 

Kuhfeld MT, Mahraoui L, Rodolosse A et al. (1994) Presence and differential expression of SGLT1, Glutl, Glut2, Glut3 and Glut5 hexose transporter mRNAs in CACO-2 cell clones in relation to cell growth and glucose consumption. Biochem J 298 629-633... 

Cellular arsenic uptake in the form of As(V) is mediated via phosphate transporters and in the form of As(III) via glyc-eroporin membrane proteins (Mukhopadhyay et al, 2003) or hexose transporters (Liu etal, 2004) or glucose permease GLUTl (Liu et al, 2006). The best characterized arsenic... 

Liu, Z., Sanchez, M.A., Jiang, X., Boles, E., Landfear, S.M., Rosen, B.P. (2006). Mammalian glucose permease GLUTl facilitates transport of arsenic trioxide and methylarsonous acid. Biochem. Biophys. Res. Commun. 351 424-30. 

Taha, C., Milsumoto, V., Liu, Z., Skolnik, E., and Klip, A. (1995). The insulin-dependent biosynthesis of GLUTl and GLUTS glucose transporters in L6 muscle cells is mediated by distinct pathways, /, Bioi. Chem. 270, 24678-2 01-... 

Ho YY, Yang H, Klepper J, Fischbarg J, Wang D, De Vivo DC. Glucose transporter type 1 deficiency syndrome (GlutlDS) methybcanthines potentiate Glutl haploinsuffi-ciency in vitro. Pediatr Res 2001 50(2) 254-60. 

Figure 8-23 Predicted topology of the human glucose transporter GLUTl. The 12 predicted helices are numbered and the single external N-linked oligosaccharide is marked CHO. The sequence RXGRR (marked) is found in many 12-helix transporters. Its occurrence in these two positions suggests that the transporters may have evolved by duplication of a 6-helix motif. However, the human glucose transporters otherwise show no sequence similarity to other 12-helix transporters. After Bell et al See also Muekler. °°...

Inukai K, Katagiri H, Takata K, Asano T, Anai M, et al. 1995. Characterization of rat GLUTS and functional analysis of chimeric proteins of GLUTl glucose transporter and GLUTS fructose transporter. Endocrinology 136 4850-4857. 

Several glucose transporters mediate the thermodynamically downhill movement of glucose across the plasma membranes of animal cells. Each member of this protein family, named GLUTl to GLUTS, consists of a single polypeptide chain about 500 residues long (Table 16.4). Each glucose transporter has a 12-transmembrane-helix structure similar to that of lactose permease (Section 13,3). 

GLUTl All mammalian tissues 1 mM Basal glucose uptake... 

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