Glucose permease

The entry rate of glucose into red blood cells is far greater than would be calculated for simple diffusion. Rather, it is an example of facilitated diffiision (Chapter 41). The specific protein involved in this process is called the glucose transporter or glucose permease. Some of its properties are summarized in Table 52-3-The process of entry of glucose into red blood cells is of major importance because it is the major fuel supply for these cells. About seven different but related glucose transporters have been isolated from various tissues unlike the red cell transporter, some of these are insidin-dependent (eg, in muscle and adipose tissue). There is considerable interest in the latter types of transporter because defects in their recruitment from intracellular sites to the surface of skeletal muscle cells may help explain the insulin resistance displayed by patients with type 2 diabetes mellitus. 

Cellular arsenic uptake in the form of As(V) is mediated via phosphate transporters and in the form of As(III) via glyc-eroporin membrane proteins (Mukhopadhyay et al, 2003) or hexose transporters (Liu etal, 2004) or glucose permease GLUTl (Liu et al, 2006). The best characterized arsenic... 

Liu, Z., Sanchez, M.A., Jiang, X., Boles, E., Landfear, S.M., Rosen, B.P. (2006). Mammalian glucose permease GLUTl facilitates transport of arsenic trioxide and methylarsonous acid. Biochem. Biophys. Res. Commun. 351 424-30. 

The Na+-K+ ATPase maintains the Na+ gradient essential to maintain membrane potential. In certain cells, glucose transport depends on the Na+ gradient. Glucose permease transports both Na+ and glucose. 

Gonzy-Treboul, G., de Waard, J. H., Zagorec, M., Postma, P. W. p991). The glucose permease of the phosphotransferase system of Bacillus subtilis evidence for 11° and III° domains. Molecular Microbiology, 5, 1241-1249. 

Meins, M. Zanolari, B. Rosenbusch, J.P. Erni, B. Glucose permease of Escherichia coli. Purification of the IIGlc subunit and functional characterization of its oligomeric forms. J. Biol. Chem., 263, 12986-12993 (1988)... 

Bachem, S. Faires, N. Stulke, J. Characterization of the presumptive phosphorylation sites of the Bacillus subtilis glucose permease by site-directed mutagenesis implication in glucose transport and catabolite repression. FEMS Microbiol. Lett, 156, 233-238 (1997)... 

Begley, G.S. Warner, K.A. Arents, J.C. Postma, P.W. Jacobson, G.R. Isolation and characterization of a mutation that alters the substrate specificity of the Escherichia coli glucose permease. J. Bacteriol., 178, 940-942 (1996)... 

Glucose passes into an erythrocyte via glucose permease by facilitated diffusion. Glucose flows using its concentration gradient via passive transport. (Adapted from Lehninger, Principles of Biochemistry, Third Edition, by David L. Nelson and Michael M. Cox. 1982, 1992, 2000 by Worth Publishers. Used with permission ofW. H. Freeman and Company.)... 

Na/glucose permease Glucose Mixed lipids ISFET ISFET 134... 

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