Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Glucose-dependent insulinotropic peptide

Glucose-dependent-insulinotropic peptide Incretin Hormones... [Pg.524]

Sitagliptin is a selective dipeptidylpeptidase 4 (DPP-4) inhibitor which increases the active form of GLP-1 (glucagon-like-peptide-1) and GIP (glucose-dependent insulinotropic peptide). This enzyme-inhibiting drug is to be used either alone or in combination with metformin or a thiazolidinedione for control of type 2 diabetes mellitus. Adverse effects were as common with sitagliptin (whether used alone or with metformin or pioglitazone) as they were with placebo, except for nausea and common cold-like symptoms. [Pg.397]

Glucose-Dependent Insulinotropic Peptide (GIP, Gastric Inhibitory Polypeptide) ... [Pg.1876]

Glucose, the principal stimulus to insulin secretion, is permissive for the action of many other secretogogues. Glucose provokes insulin secretion more effectively when taken orally than when administered intravenously because the oral route induces the release of GI hormones and stimulates vagal activity. Several GI hormones promote insulin secretion, the most potent of which are glucose-dependent insulinotropic peptide (GIP, also known as gastrointestinal inhibitory peptide) and glucagon-like peptide-1 (GLP-1). [Pg.1038]

Dipeptidyl peptidase 4 (DPP-4) is a ubiquitous proline-specific serine protease responsible for the rapid inactivation of inaetins, including glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic peptide. To alleviate the inactivation of GLP-1, inhibitors of DPP-IV are being evaluated for their abihty to provide improved control of blood glucose for diabetics [187-189]. [Pg.379]

Antidiabetic Drugs other than Insulin. Table 3 Actions of the incretin hormones GIP (glucose-dependent insulinotropic polypeptide, gastric inhibitory peptide) and GLP-1 (glucagon-like peptide-1)... [Pg.122]

R. P. Pauly, F. Rosche, M. Wermann, C. H. McIntosh, R. A. Pederson, and H. U. Demuth. Investigation of Glucose-Dependent Insulinotropic Polypeptide-(l-42) and Glucagon-like Peptide-1-(7-36) Degradation In Vitro by Dipeptidyl Peptidase IV Using Matrix-Assisted... [Pg.81]

The approval of sitagliptin (1) by the U.S. FDA in 2006 established dipeptidyl peptidase IV (DPP-4) inhibitors as an important new therapy for the treatment of type 2 diabetes.4 7 DPP-4 inhibitors stimulate insulin secretion indirectly by enhancing the action of the incretin hormones glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (G1P). GLP-1 and G1P stimulate insulin secretion in a... [Pg.125]

GIP, gastric inhibitory peptide, glucose-dependent insulinotropic. polypeptide Glc, (3-D-gluc.ose... [Pg.842]

Glucose-dependent insulinotropic polypeptide (GIP) GIP receptor 42-residue peptide Inhibit gastric acid and stimulate insulin secretion Solution-phase chemistry... [Pg.2181]

Glucose-dependent insulinotropic polypeptide is originally known as gastric inhibitory polypeptide (GIP), which is a 42-residue peptide first isolated by Brown and Dryburgh (14). It is secreted from the duodenum and proximal jejunum in response to food. Two major physiological effects of GIP are inhibition of gastric acid secretion and stimulation of insulin release. [Pg.2187]

GIP Glucose-dependent-insulinotropic polypeptide = Gastric inhibitory peptide... [Pg.253]

Fig. 1. Peptide structures of the two main incretin hormones, glucose-dependent insulinotropic polypeptide (gastric inhibitory polypeptide, GIP), and glucagon-like peptide 1 (GLP-1). Amino acids shared between both peptides are shown in dark blue, and amino acids unique to GIP and GLP-1 are shown in light and dark green, respectively. The red arrow indicates the position of cleavage by dipeptidyl peptidase-4 (DPP-4), the alanine residue in position 2, which is recognized by DPP-4, is highlighted by a red margin. Fig. 1. Peptide structures of the two main incretin hormones, glucose-dependent insulinotropic polypeptide (gastric inhibitory polypeptide, GIP), and glucagon-like peptide 1 (GLP-1). Amino acids shared between both peptides are shown in dark blue, and amino acids unique to GIP and GLP-1 are shown in light and dark green, respectively. The red arrow indicates the position of cleavage by dipeptidyl peptidase-4 (DPP-4), the alanine residue in position 2, which is recognized by DPP-4, is highlighted by a red margin.
Kieffer TJ, McIntosh CH, Pederson RA. Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-hke peptide 1 in vitro and in vivo by dipeptidyl peptidase IV. Endocrinology 1995 136 3585-3596. [Pg.136]

Hlebowicz, J., A. Hlebowicz, S. Lindstedt, et al. 2009. Effects of 1 and 3 g cinnamon on gastric emptying, satiety, and postprandial blood glucose, insulin, glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1, and ghrelin concentrations in healthy subjects. Am. J. Clin. Nutr. 89(3) 815-821. [Pg.212]

See other pages where Glucose-dependent insulinotropic peptide is mentioned: [Pg.507]    [Pg.98]    [Pg.131]    [Pg.757]    [Pg.386]    [Pg.99]    [Pg.1876]    [Pg.400]    [Pg.507]    [Pg.98]    [Pg.131]    [Pg.757]    [Pg.386]    [Pg.99]    [Pg.1876]    [Pg.400]    [Pg.121]    [Pg.657]    [Pg.541]    [Pg.401]    [Pg.418]    [Pg.947]    [Pg.69]    [Pg.121]    [Pg.126]    [Pg.24]    [Pg.1055]    [Pg.800]    [Pg.145]    [Pg.175]    [Pg.340]    [Pg.427]    [Pg.166]    [Pg.168]   
See also in sourсe #XX -- [ Pg.131 ]

See also in sourсe #XX -- [ Pg.1876 ]



SEARCH



Glucose-dependent insulinotropic

Insulinotropic

© 2024 chempedia.info