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Insulinotropic

Antidiabetic Drugs other than Insulin. Table 3 Actions of the incretin hormones GIP (glucose-dependent insulinotropic polypeptide, gastric inhibitory peptide) and GLP-1 (glucagon-like peptide-1)... [Pg.122]

Glucose-dependent-insulinotropic peptide Incretin Hormones... [Pg.524]

An efficient biocatalytic method for the production of amides in multigrara scale has been developed for the synthesis of a pyrrole-amide, which is an intermediate for the synthesis of the dipeptidyl peptidase IV that regulates plasma levels of the insulinotropic proglucagon. CALB catalyzes the ammonolysis of the ester with ammonium carbamate as source of ammonia (Scheme 7.8) [22]. The use of ascarite and calcium chloride as adsorbents for carbon dioxide and ethanol by-products. [Pg.176]

Gordienko D V, Bolton TB, Cannell MB 1998 Variability in spontaneous subcellular Ca2+ release in guinea-pig ileum smooth muscle cells. J Physiol 507 707-720 Ho R, Shao Z 1991 Axial resolution of confocal microscopes revisited. Optiik 88 147—154 Holz GG, Leech CA, Heller RS, Castonguay N, Habener JF 1999 cAMP-dependent mobilization of intracellular Ca2+ stores by activation of ryanodine receptors in pancreatic [j cells. A Ca2+ signaling system stimulated by the insulinotropic hormone glucagon-like peptide-1-(7-37). J Biol Chem 274 14147-14156 Lipsius SL, Hiiser J, Blatter LA 2001 Intracellular Ca2+ release sparks atrial pacemaker activity. News Physiol Sci 16 101-106... [Pg.173]

R. P. Pauly, F. Rosche, M. Wermann, C. H. McIntosh, R. A. Pederson, and H. U. Demuth. Investigation of Glucose-Dependent Insulinotropic Polypeptide-(l-42) and Glucagon-like Peptide-1-(7-36) Degradation In Vitro by Dipeptidyl Peptidase IV Using Matrix-Assisted... [Pg.81]

FSIP frog skin insulinotropic peptide from frog Agalychnis litodryas G (Gly) glycine or glycyl... [Pg.298]

Ko BS, Choi SB, Park SK, Jang JS, Kim YE, Park S. (2005) Insulin sensitizing and insulinotropic action of berberine from Cortidis rhizoma. Biol Pharm Bull 28 1431-1437. [Pg.585]

Jeppesen PB, Gregersen S, Alstrup KK, Hermansen K. (2002) Stevioside induces antihyperglycaemic, insulinotropic and glucagonostatic effects in vivo Studies in the diabetic Goto-Kakizaki (GK) rats. Phytomedicine 9 9-14. [Pg.586]

Sitagliptin is a selective dipeptidylpeptidase 4 (DPP-4) inhibitor which increases the active form of GLP-1 (glucagon-like-peptide-1) and GIP (glucose-dependent insulinotropic peptide). This enzyme-inhibiting drug is to be used either alone or in combination with metformin or a thiazolidinedione for control of type 2 diabetes mellitus. Adverse effects were as common with sitagliptin (whether used alone or with metformin or pioglitazone) as they were with placebo, except for nausea and common cold-like symptoms. [Pg.397]

Carroll MF, Gutierrez A, Castro M, Tsewang D, Schade DS. Targeting postprandial hyperglycemia a comparative study of insulinotropic agents in type 2 diabetes. J Cin Endocrinol Metab 2003 88 5248-54. [Pg.457]

Salhanick AI, Clairmont KB, Buckholz TM, Pellegrino CM, Ha S, Lumb KJ (2005) Contribution of site-specific PEGylation to the dipeptidyl peptidase IV stability of glucose-dependent insulinotropic polypeptide. Bioorg Med Chem Lett 15 4114-4117 Sanderink G-J, Artur Y, Siest G (1988) Human aminopeptidase a review of the literature. J Clin Chem Clin Biochem 26 795-807... [Pg.84]

The approval of sitagliptin (1) by the U.S. FDA in 2006 established dipeptidyl peptidase IV (DPP-4) inhibitors as an important new therapy for the treatment of type 2 diabetes.4 7 DPP-4 inhibitors stimulate insulin secretion indirectly by enhancing the action of the incretin hormones glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (G1P). GLP-1 and G1P stimulate insulin secretion in a... [Pg.125]

Broca, C., Cross, R., Petit, P., Sanvaire, Y., Manteghetti, M.,Tournies, M., Masiello, P., Gonnis, R. and Riber, C. (1 999) 4-Hydroxy isoleucine - experimental evidence of its insulinotropic and antidiabetic properties. American Journal of Physiology 277(4), E61 7-E623. [Pg.256]

Table 14.6 Plant compounds with hypoglycaemic, antidiabetic and/or insulinotropic effects ... Table 14.6 Plant compounds with hypoglycaemic, antidiabetic and/or insulinotropic effects ...
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Glucose-dependent insulinotropic peptide

Glucose-dependent insulinotropic polypeptide

Glucose-dependent insulinotropic receptor

Insulinotropic agents

Sulfonylurea insulinotropic

Sulfonylurea insulinotropic agents

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