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Gastric inhibitory polypeptide

Improved stability with simultaneous preservation of activity has been demonstrated with analogues of glucagon-like peptide-1 and gastric inhibitory polypeptide, two hormones that stimulate the release of insulin. Glucagon-like peptide-1 (GLP-1) is a 30-residue gastrointestinal hormone, ami-dated at the C-terminus that has potential as a treatment for type-2 diabetes. However, GLP-1 is rapidly degraded by dipeptidyl-peptidase IV (EC... [Pg.342]

E P. M. O Harte, M. H. Mooney, P. R. Flatt, NH2-Terminally Modified Gastric Inhibitory Polypeptide Exhibits Aminopeptidase Resistance and Enhanced Antihyperglyce-mic Activity , Diabetes 1999, 48, 758 - 765. [Pg.379]

As linear polypeptides, VIP (vasoactive intestinal polypeptide)105), PHI (peptide HI H = N-terminal His, I = C-terminal lie) lo6107) and GIP (gastric inhibitory polypeptide consisting of 43 amino acids)108) are structurally similar to secretin and glucagon. VIP and PHI act as vasodilators, exert hyperglycemic effects, and affect the smooth muscle of the gallbladder. GIP completely blocks gastric secretion. [Pg.125]

Glucose-dependent insulinotropic polypeptide is originally known as gastric inhibitory polypeptide (GIP), which is a 42-residue peptide first isolated by Brown and Dryburgh (14). It is secreted from the duodenum and proximal jejunum in response to food. Two major physiological effects of GIP are inhibition of gastric acid secretion and stimulation of insulin release. [Pg.2187]

Brown JC, Dryburgh Jr. Gastric inhibitory polypeptide. II. Complete amino acid sequence. Can. J. Biochem. 1971 49 867-872. [Pg.2206]

K, Torizuka K, Adachi H, Imura H, Taminato T. Synthesis of 34. the tritetracontapeptide corresponding to the entire amino acid sequence of gastric inhibitory polypeptide. J. Am. Chem. Soc. 35. 1975 97 5593-5594. [Pg.2206]

Brown JB, Mutt V. Amino acid sequence and heterogeneity of 36. gastric inhibitory polypeptide (GIP). FEBS Lett. 1981 123 205-... [Pg.2206]

Mochizuki T, Yanaihara C, Mutt V, Brown JC, Yanaihara N. 37. 1982. Synthesis of porcine GIP (Gastric Inhibitory Polypeptide). [Pg.2206]

Follicle stimulating hormone Growth hormone Gastric inhibitory polypeptide Gonadotropin releasing hormone... [Pg.276]

Glucose-Dependent Insulinotropic Peptide (GIP, Gastric Inhibitory Polypeptide) ... [Pg.1876]

Gastric Inhibitory Polypeptide - (G.I.P.) is a 43 amino acid polypeptide released by glucose and fat ingestion. In addition to its insulinotrophic effects in animals and man, G.I.P. inhibits acid secretion in... [Pg.94]

LI. Lauritzen, J. B., Lauritzen, K. B., Olsen, M. E., and Timmerman, I., Gastric inhibitory polypeptide (GIP) and insulin release in response to oral and intravenous glucose in uremic patients. Metab., Clin. Exp. 31, 1096-1099 (1982). [Pg.111]

Gastric inhibitory polypeptide/ Neuroendocrine K cells of 1. Increases insulin release via an Oral nutrient ingestion, especially... [Pg.800]

Gastric inhibitory polypeptide, glucose-dependent insulinotropic polypeptide. [Pg.139]

Neuromedin C (NMC), H-Gly-Asn-His-Trp-Ala-Val-Gly-His-Leu-Met -NH2, a bombesin-like peptide identified in porcine spinal cord. It exhibits a potent stimulant effect on the smooth muscle of rat uterus. NMC shows sequence identity with the C-terminal part 18-27 of gastric-inhibitory polypeptide and sequence homology with the C-terminus of bombesin. The name NMC was coined since it is closely related to —> neuromedin B [N. Minamino et al., Biochem. Biophys. Res. Commun. 1984, 119, 14 G. Gasmi et al., J. Peptide Res. 1997, 49, 500]. [Pg.239]

Keywords Incretiii, glucagon-Mke peptide-1 (GLP-1), gastric inhibitory polypeptide (GIP), entero-insular axis, exenatide, liraglutide, vildagliptin, sitagliptin, saxagliptin, DPP-4. [Pg.111]

The fu-st incretin to be identified, GIP, was purified from porcine intestine extracts by virme of its ability to inhibit gastric acid secretion (therefore, the original name was gastric inhibitory polypeptide) [7,24]. Soon, it was discovered that GIP displayed potent insulinotropic actions in animals [8,25] and in human subjects [9]. GIP was shown to be a 42 amino acid peptide hormone... [Pg.112]

Fig. 1. Peptide structures of the two main incretin hormones, glucose-dependent insulinotropic polypeptide (gastric inhibitory polypeptide, GIP), and glucagon-like peptide 1 (GLP-1). Amino acids shared between both peptides are shown in dark blue, and amino acids unique to GIP and GLP-1 are shown in light and dark green, respectively. The red arrow indicates the position of cleavage by dipeptidyl peptidase-4 (DPP-4), the alanine residue in position 2, which is recognized by DPP-4, is highlighted by a red margin. Fig. 1. Peptide structures of the two main incretin hormones, glucose-dependent insulinotropic polypeptide (gastric inhibitory polypeptide, GIP), and glucagon-like peptide 1 (GLP-1). Amino acids shared between both peptides are shown in dark blue, and amino acids unique to GIP and GLP-1 are shown in light and dark green, respectively. The red arrow indicates the position of cleavage by dipeptidyl peptidase-4 (DPP-4), the alanine residue in position 2, which is recognized by DPP-4, is highlighted by a red margin.
Pederson RA, Brown JC. The insulinotropic action of gastric inhibitory polypeptide in the perfused rat pancreas. Endocrinology 1976 99 780-785. [Pg.130]

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