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Gastric inhibitory peptide

Gastric inhibitory peptide (GIP) is found in the K cells of the duodenum and jejunum It consists of 43 amino acid residues and occurs in multiple molecular forms. Its secretion is stimulated by the presence of glucose and lipids in the duodenum. It has two main functions  [Pg.208]

To stimulate insulin secretion that prepares the appropriate tissues for the transport and metabolism of nutrients obtained from the GI tract (Chapter 22), and [Pg.208]

Antidiabetic Drugs other than Insulin. Table 3 Actions of the incretin hormones GIP (glucose-dependent insulinotropic polypeptide, gastric inhibitory peptide) and GLP-1 (glucagon-like peptide-1)... [Pg.122]

Incretins gut hormones that increase glucose-stimulated insulin secretion GLP-1 glucagon-like peptide-1 GDP Gastric inhibitory peptide or glucose-dependent insulino-tropic peptide... [Pg.623]

As the volume of the chyme in the duodenum increases, it causes distension of the duodenal wall and stimulation of mechanoreceptors. This receptor stimulation elicits reflex inhibition of gastric motility mediated through the intrinsic and vagus nerves. Distension also causes release of gastric inhibitory peptide from the duodenum, which contributes to inhibition of gastric contractions. [Pg.290]

Gastric inhibitory peptide (GIP) Polypeptide (43 residues) Inhibits gastrin secretion... [Pg.573]

Fig. 7. (A) Aligned, partial sequences of a number of calmodulin-binding peptides. The boxes indicate residues that are generally occupied by apolar residues. Reported dissociation constants for interaction with calmodulin are given on the right. LK2, A mode peptide VIP, vasoactive intestinal peptide GIP, gastric inhibitory peptide. (B) The mean hydropho-bicities for the residues at a given position were plotted versus their position in the aligned sequence. The horizontal bar indicates the period of an a helix. From Cox et al. (1985). Fig. 7. (A) Aligned, partial sequences of a number of calmodulin-binding peptides. The boxes indicate residues that are generally occupied by apolar residues. Reported dissociation constants for interaction with calmodulin are given on the right. LK2, A mode peptide VIP, vasoactive intestinal peptide GIP, gastric inhibitory peptide. (B) The mean hydropho-bicities for the residues at a given position were plotted versus their position in the aligned sequence. The horizontal bar indicates the period of an a helix. From Cox et al. (1985).
Gastric inhibitory peptide acts via a GPCR on pancreatic (1 cells to promote insulin secretion. The plant natural products gymnemic acid and phloridzin inhibit D-glucose binding to the GI glucose receptor involved in glucose-stimulated GIP secretion. [Pg.165]

GIP, gastric inhibitory peptide, glucose-dependent insulinotropic. polypeptide Glc, (3-D-gluc.ose... [Pg.842]

Hormones related by the entero-insular axis which may be of significance for insulin release are CCK, gastric inhibitory peptide (GIP) and glucagonlike peptide (GLP). [Pg.98]

GIP Glucose-dependent-insulinotropic polypeptide = Gastric inhibitory peptide... [Pg.253]

Gastric inhibitory peptide Stimulation of TAG storage and amplification... [Pg.233]

Release of gastrin, cholecystokinin, gastric inhibitory peptide, and glicentin appears to stimulate insulin release in an anticipatory manner in addition to regulating other digestive responses. [Pg.498]

In addition to the decreased intestinal absorption of calcium in uremia, calcium ATPase activity is also low (S6). Many gastrointestinal hormones are found in increased concentrations in uremia. These include gastrin (OlO), cholecystokinin (OlO), pepsinogen I (II), gastric inhibitory peptide (LI), amylase, and trypsin (R17). There is a decrease in the conjugation of cholic to deoxycholic acid (G13) and in the pancreatic secretion of bicarbonate (Oil). Hepatic output of urea is decreased, as is the activity of some urea cycle enzymes e.g., ornithine tran-scarbamylase (T9). The clinical significance of these hormonal and enzymatic perturbations remains to be elucidated. [Pg.91]

See other pages where Gastric inhibitory peptide is mentioned: [Pg.524]    [Pg.537]    [Pg.1492]    [Pg.290]    [Pg.291]    [Pg.291]    [Pg.507]    [Pg.852]    [Pg.80]    [Pg.417]    [Pg.165]    [Pg.274]    [Pg.57]    [Pg.524]    [Pg.537]    [Pg.126]    [Pg.594]    [Pg.972]    [Pg.133]    [Pg.113]    [Pg.203]    [Pg.203]    [Pg.208]    [Pg.701]    [Pg.100]    [Pg.822]   
See also in sourсe #XX -- [ Pg.284 ]

See also in sourсe #XX -- [ Pg.573 ]

See also in sourсe #XX -- [ Pg.165 , Pg.221 ]

See also in sourсe #XX -- [ Pg.203 , Pg.208 , Pg.267 , Pg.701 ]

See also in sourсe #XX -- [ Pg.2616 ]



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