Glucose-dependent insulinotropic

Antidiabetic Drugs other than Insulin. Table 3 Actions of the incretin hormones GIP (glucose-dependent insulinotropic polypeptide, gastric inhibitory peptide) and GLP-1 (glucagon-like peptide-1)... [Pg.122]

Glucose-dependent-insulinotropic peptide Incretin Hormones... [Pg.524]

R. P. Pauly, F. Rosche, M. Wermann, C. H. McIntosh, R. A. Pederson, and H. U. Demuth. Investigation of Glucose-Dependent Insulinotropic Polypeptide-(l-42) and Glucagon-like Peptide-1-(7-36) Degradation In Vitro by Dipeptidyl Peptidase IV Using Matrix-Assisted... [Pg.81]

Sitagliptin is a selective dipeptidylpeptidase 4 (DPP-4) inhibitor which increases the active form of GLP-1 (glucagon-like-peptide-1) and GIP (glucose-dependent insulinotropic peptide). This enzyme-inhibiting drug is to be used either alone or in combination with metformin or a thiazolidinedione for control of type 2 diabetes mellitus. Adverse effects were as common with sitagliptin (whether used alone or with metformin or pioglitazone) as they were with placebo, except for nausea and common cold-like symptoms. [Pg.397]

Salhanick AI, Clairmont KB, Buckholz TM, Pellegrino CM, Ha S, Lumb KJ (2005) Contribution of site-specific PEGylation to the dipeptidyl peptidase IV stability of glucose-dependent insulinotropic polypeptide. Bioorg Med Chem Lett 15 4114-4117 Sanderink G-J, Artur Y, Siest G (1988) Human aminopeptidase a review of the literature. J Clin Chem Clin Biochem 26 795-807... [Pg.84]

The approval of sitagliptin (1) by the U.S. FDA in 2006 established dipeptidyl peptidase IV (DPP-4) inhibitors as an important new therapy for the treatment of type 2 diabetes.4 7 DPP-4 inhibitors stimulate insulin secretion indirectly by enhancing the action of the incretin hormones glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (G1P). GLP-1 and G1P stimulate insulin secretion in a... [Pg.125]

GIP, gastric inhibitory peptide, glucose-dependent insulinotropic. polypeptide Glc, (3-D-gluc.ose... [Pg.842]

Glucose-dependent insulinotropic polypeptide (GIP) GIP receptor 42-residue peptide Inhibit gastric acid and stimulate insulin secretion Solution-phase chemistry... [Pg.2181]

Glucose-dependent insulinotropic polypeptide is originally known as gastric inhibitory polypeptide (GIP), which is a 42-residue peptide first isolated by Brown and Dryburgh (14). It is secreted from the duodenum and proximal jejunum in response to food. Two major physiological effects of GIP are inhibition of gastric acid secretion and stimulation of insulin release. [Pg.2187]

Human-glucose-dependent insulinotropic polypeptide (human GIP) was synthesized by the route shown in Scheme Trimethylsilyl trifluoromethanesulfonate (TMSOTf) has also... [Pg.622]

Musso G, Gambino R, Pacini G, De Michieli F, Cassader M. Prolonged saturated fat-induced, glucose-dependent insulinotropic polypeptide elevation is associated with adipokine imbalance and liver injury in nonalcoholic steatohepati-tis Dysregulated enteroadipocyte axis as a novel feature of fatty liver. Am J Clin Nutr. 2009 89(2) 55 8-567. [Pg.72]

Postprandial glucose-dependent insulinotropic polypeptide (GIP) levels were lowered in a guar-gum-supplemented meal (Morgan et al., 1990) and may contribute to lower insulin levels. Guar delays intestinal calcium absorption in humans (Gulliford et al., 1988b). The decrease in pancreatic amylase release may simply be a result of diminished insular-exocrine axis. [Pg.152]

GIP Glucose-dependent-insulinotropic polypeptide = Gastric inhibitory peptide... [Pg.253]

Glucose-Dependent Insulinotropic Peptide (GIP, Gastric Inhibitory Polypeptide) ... [Pg.1876]

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