Glucose blood levels after infusion

In a typical experiment, noninvasive spectra are collected continuously as the in vivo glucose concentration is controlled by intravenous infusion of fluids.50 Glucose concentrations are held low and constant for the first 3 h. Then, glucose concentrations are increased to more than 30 mM. Glucose is maintained at this level for approximately 1 h, after which the glucose concentration is allowed to decay naturally to basal levels over the next hour. During the course of the experiment, arterial blood samples are collected periodically for analysis by a standard reference method. 

FIGURE 3.4 Measured plasma concentrations of insulin in compartment 1 (intravascular space) after intravenous injection of a 25-mU/kg dose, and computer-derived estimates of insulin concentration in presumed splanchnic (compartment 2) and somatic (compartment 3) components of interstitial fluid space. The bar graph indicates the glucose infusion rate needed to maintain blood glucose concentrations at the basal level. (Reproduced with permission from ShenA in RS, Kramer KJ, Tobin JD, Insel PA, Liljenquist JE, Berman M, Andres R. J Clin Invest 1974 53 1481-92.)... 

Distinctive sugars. The intravenous infusion of fructose into healthy volunteers leads to a two- to fivefold increase in the level of lactate in the blood, a far greater increase than that observed after the infusion of the same amount of glucose. 

A 16-year-old insulin-dependent diabetic patient was admitted to the hospital with a blood glucose of 400 mg/dl. (The reference range for blood glucose is 80-100 mg/dl). One hour after an insulin infusion was begun, her blood glucose had decreased to 320 mg/dl. One hour later, it was 230 mg/dl. The patient s glucose level decreased because insulin... 

Fig. 5. Blood glucose and plasma counter-regulatory hormone levels before, during and after a constant intravenous insulin infusion. = P 0.05 versus basal 0= n.s. versus basal. (Source Bolli et al., 1984c.)...

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