Glucocorticoid-responsive

Arriza, J., Simerly, R., Swanson, L. and Evans, R. The neuronal mineralocorticoid receptor as mediator of glucocorticoid response. Neuron 1 887-896,1988. 

Phosphoenolpyruvate carboxykinase (PEPCK) catalyzes a critical reaction in gluconeogenesis, which under many conditions is the rate-limiting step in the pathway. A cAlVfP response element (CRE) and a glucocorticoid response element (GRE) are each located upstream from the transcription start site. 

Binds (through the zinc fingers) to the glucocorticoid response element (GRE) associ-. ated with the PEPCK gene, which... 

Glucocorticoids induce cataract formation, particularly in patients with rheumatoid arthritis. An increase in intraocular pressure related to a decreased outflow of aqueous humor is also a frequent side effect of periocular, topical, or systemic administration. Induction of ocular hypertension, which occurs in about 35% of the general population after glucocorticoid administration, depends on the specific drug, the dose, the frequency of administration, and the glucocorticoid responsiveness of the patient. 

Kemppainen RJ, Cox E, Behrend EN, Brogan MD, Ammons JM (2003) Identification of a glucocorticoid response element in the 3 -flanking region of the human Dexrasl gene. Biochim Biophys Acta 1627 85-89... 

Cortisol, corticosterone, aldosterone, and the synthetic steroids used in steroid therapy (e.g., prednisolone, dexamethasone, and triamcinolone) are glucocorticoid agonists and therefore elicit glucocorticoid responses. A number of other steroids bind to the glucocorticoid receptor and thus suppress glucocorticoid responses. 

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