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Glucocorticoid agonist

Synthetic steroid with strong glucocorticoid-agonistic activity. Dexamethasone is over 10 times more potent than cortisol due to a higher binding affinity for glucocorticoid receptor and a decreased clearance rate of the compound. Due to its potency, dexamethasone is widely used in the clinics for the treatment of inflammatory diseases. [Pg.422]

Corticosteroids Glucocorticoid agonists Steroids Asthma controllers... [Pg.538]

Cortisol, corticosterone, aldosterone, and the synthetic steroids used in steroid therapy (e.g., prednisolone, dexamethasone, and triamcinolone) are glucocorticoid agonists and therefore elicit glucocorticoid responses. A number of other steroids bind to the glucocorticoid receptor and thus suppress glucocorticoid responses. [Pg.556]

Lessons in array driven iead optimization with an example from the discovery of orally bioavailable glucocorticoid agonists... [Pg.237]

Asthma attacks less than twice a week FEV1 >80% Rapid-acting inhaled p2-agonist Low dose inhaled glucocorticoid or cromone (children)... [Pg.288]

Asthma attacks more than twice a week FEV1 60-80% daily use of bronchodilators. Rapid-acting inhaled p2-agonist Inhaled glucocorticoid... [Pg.288]

Severe, life-threatening asthma attacks inhaled p2-agonists ineffective Oxygen Glucocorticoids oral or i.v. [Pg.288]

Several steroidal and non-steroidal glucocorticoid receptor selective dissociated agonists are in development by many pharmaceutical companies and some are now in clinical development. This suggests that the development of dissociated glucocorticoids with a greater margin of safety is possible and may even lead to the development of oral compounds that do not have significant adverse effects. [Pg.542]

TSH 0.S-2.S milliunits/L (0.5-2.5 microunits/mL)a Gold standard may be lowered by dopamine, dopamine agonists, glucocorticoids, octreotide, recovery from severe nonthyroidal illness... [Pg.669]


See other pages where Glucocorticoid agonist is mentioned: [Pg.98]    [Pg.108]    [Pg.547]    [Pg.889]    [Pg.98]    [Pg.108]    [Pg.908]    [Pg.926]    [Pg.105]    [Pg.50]    [Pg.547]    [Pg.98]    [Pg.108]    [Pg.99]    [Pg.135]    [Pg.104]    [Pg.349]    [Pg.63]    [Pg.98]    [Pg.108]    [Pg.547]    [Pg.889]    [Pg.98]    [Pg.108]    [Pg.908]    [Pg.926]    [Pg.105]    [Pg.50]    [Pg.547]    [Pg.98]    [Pg.108]    [Pg.99]    [Pg.135]    [Pg.104]    [Pg.349]    [Pg.63]    [Pg.98]    [Pg.7]    [Pg.186]    [Pg.188]    [Pg.367]    [Pg.480]    [Pg.541]    [Pg.541]    [Pg.547]    [Pg.756]    [Pg.894]    [Pg.968]    [Pg.982]    [Pg.43]    [Pg.668]    [Pg.499]    [Pg.175]    [Pg.497]    [Pg.573]    [Pg.84]   
See also in sourсe #XX -- [ Pg.18 ]




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Glucocorticoids

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