Glucocorticoid agonist

Synthetic steroid with strong glucocorticoid-agonistic activity. Dexamethasone is over 10 times more potent than cortisol due to a higher binding affinity for glucocorticoid receptor and a decreased clearance rate of the compound. Due to its potency, dexamethasone is widely used in the clinics for the treatment of inflammatory diseases. 

Corticosteroids Glucocorticoid agonists Steroids Asthma controllers... 

Cortisol, corticosterone, aldosterone, and the synthetic steroids used in steroid therapy (e.g., prednisolone, dexamethasone, and triamcinolone) are glucocorticoid agonists and therefore elicit glucocorticoid responses. A number of other steroids bind to the glucocorticoid receptor and thus suppress glucocorticoid responses. 

Lessons in array driven iead optimization with an example from the discovery of orally bioavailable glucocorticoid agonists... 

Asthma attacks less than twice a week FEV1 >80% Rapid-acting inhaled p2-agonist Low dose inhaled glucocorticoid or cromone (children)... 

Asthma attacks more than twice a week FEV1 60-80% daily use of bronchodilators. Rapid-acting inhaled p2-agonist Inhaled glucocorticoid... 

Severe, life-threatening asthma attacks inhaled p2-agonists ineffective Oxygen Glucocorticoids oral or i.v. 

Several steroidal and non-steroidal glucocorticoid receptor selective dissociated agonists are in development by many pharmaceutical companies and some are now in clinical development. This suggests that the development of dissociated glucocorticoids with a greater margin of safety is possible and may even lead to the development of oral compounds that do not have significant adverse effects. 

TSH 0.S-2.S milliunits/L (0.5-2.5 microunits/mL)a Gold standard may be lowered by dopamine, dopamine agonists, glucocorticoids, octreotide, recovery from severe nonthyroidal illness... 

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