Glucocorticoid-responsive elements GREs

Phosphoenolpyruvate carboxykinase (PEPCK) catalyzes a critical reaction in gluconeogenesis, which under many conditions is the rate-limiting step in the pathway. A cAlVfP response element (CRE) and a glucocorticoid response element (GRE) are each located upstream from the transcription start site. 

Binds (through the zinc fingers) to the glucocorticoid response element (GRE) associ-. ated with the PEPCK gene, which... 

In addition to PXR and CAR, other NRs are also involved in the regulation of CYP3A expression. For example, activation of the GR by dexamethasone increases the expression of both PXR and CAR through glucocorticoid response elements (GREs) in their promoters, and this can increase the expression of CYP3AS S6. The transcription factor hepatocyte nuclear factor-4 (HNF-... 

C. Effects See Chapter 39 for details. Glucocorticoids bind to intracellular receptors and activate glucocorticoid response elements (GREs) in the nucleus, resulting in synthesis of substances that prevent the full expression of inflammation and allergy. Reduced activity of phospholipase A is thought to be particularly important in asthma because the leukotrienes that result from eicosanoid synthesis are extremely potent bronchoconstrictors and may also participate in the late inflammatory response (Figure 20-4). 

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