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Glucocerebrosidase

Cerezyme is produced in a CHO cell line harbouring the cDNA coding for human S-glucocerebrosidase. The purified product is presented as a freeze-dried powder and also contains mannitol, sodium citrate, citric acid and polysorbate 80 as excipients. It exhibits a shelf-life of 2 years when stored at 2°C-8°C. [Pg.394]

CH12 RECOMBINANT BLOOD PRODUCTS AND THERAPEUTIC ENZYMES [Pg.360]

M. K. Bijsterbosch, W. Donker, H. Van de Bilt, S. Van Weely, T. J. Van Berkel, and J. M. Aerts, Quantitative analysis of the targeting of mannose-terminal glucocerebrosidase. Predominant uptake by liver endothelial cells, Eur. J. Biochem., 237 (1996) 344-349. [Pg.386]

B. Friedman, K. Vaddi, C. Preston, E. Mahon, J. R. Cataldo, and J. M. A. McPherson, Comparison of the pharmacological properties of carbohydrate remodeled recombinant and placental-derived /i-Glucocerebrosidase Implications for clinical efficacy in treatment of Gaucher disease, Blood, 93 (1999) 2807-2816. [Pg.386]

Low-density protein receptor Adenosine deaminase Purine nucleoside phosphorylase Sphingomylinase Glucocerebrosidase... [Pg.439]

Barton, N. W., Brady, R. O., Dambrosia, J. M. et al. Replacement therapy for inherited enzyme deficiency-macrophage-targeted glucocerebrosidase for Gaucher s disease. N. Engl. J. Med. 324 1464-1470,1991. [Pg.694]

Takagi Y, Kriehubner E, Imokawa G, Elias G, and Holleran WM (1999) 6-Glucocerebrosidase activity in mammalian stratum corneum. J. Lipid Res. 40 861-869. [Pg.180]

Gaucher Glucocerebrosidase Glucocerebroside Type 1 Adult Hepatosplenomegaly Erosion of bones, fractures Pancytopenia or thrombocytopenia Characteristic macrophages (crumpled paper inclusions)... [Pg.234]

GLUCOCEREBROSIDASE GLUCOKINASE GLUCONATE DEHYDRATASE Gluconeogenesis tracer kinetics,... [Pg.745]

GLUCOSE TRACER KINETICS Glucosylceramide j8-D-glucosidase, GLUCOCEREBROSIDASE GLUCURONATE-1-PHOSPHATE URIDYLYL-TRANSFERASE... [Pg.746]

In an important contribution, Overkleeft, Aerts, and coworkers introduced adaman-tyl-terminated A-alky I substituents, which provided excellent inhibitors, for example, 67 (Scheme 18), of non-lysosomal glucosylceramidase and glucocerebrosidase.362... [Pg.250]

Notably, only very few directed, nonpolar contacts were found in the comparison of A-butyl-1-deoxynojirimycin (131, Scheme 33 PDB 2V3D) and its A-nonyl analogue (132 PDB 2V3E) in the active site of glucocerebrosidase.269 Neither their numbers nor the difference between the individual contacts for compounds 131 and 132 readily explains the striking difference in biological activity when compared to each other as well as to the parent compound 2. [Pg.252]

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Glucocerebrosidase deficiency

Glucocerebrosidase human placental

Glucocerebrosidase macrophage targeted

Glucocerebrosidase mannose-terminal,

Glucocerebrosidase therapeutic enzyme

P-Glucocerebrosidase

Recombinant glucocerebrosidase

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