Glomerulonephritis Anti-glomerular membrane

Various experimental procedures were described as models for glomerulonephritis in human beings. Most of them were developed in rats and rabbits. They involve the reactions of antibodies against renal components, such as Masugi nephritis (Masugi and Sato 1934), Heymann nephritis (Heymann 1959), nephrotoxic serum nephritis (Unanue and Dixon 1967), crescentic type anti-glomerular membrane nephritis (Nagoe et al. 1994, 1998), anti-Thyl nephritis (Chen etal. 1999). 

Hayashi et al. (1996) tested the effects of a flavonoid in original-type anti-glomerular basement membrane antibody associated glomerulonephritis in male Sprague Dawley rats on upregulation of intracellular adhesion molecule expression and on increase in leukocyte function-associated antigen positive cells in nephritic glomeruli. 

Hayashi K, Nagematsu T, Honda S, Suzuki Y (1996) Butein (3,4,2 ,4 -tetrahydroxychalcone) ameliorates experimental anti-glomerular basement membrane antibody-associated glomerulonephritis. Eur J Pharmacol... 

Bonzel KE, Miiller-Wiefel DE, Ruder H, Wingen AM, Waldherr R, Weber M. Anti-glomerular basement membrane antibody-mediated glomerulonephritis due to glue sniffing. Eur J Pediatr 1987 146(3) 296-300. 

Guery JC, Druet E, Glotz D, Hirsch F, Mandet C, De Heer E,and Druet P. Specificity and cross-reactive idiotypes of anti-glomerular basement membrane autoantibodies in HgCl2-induced autoimmune glomerulonephritis. European Journal of Immunology 20 93-100,1990. 

Lerner RA, Glassock RJ, Dixon FJ. The role of anti-glomerular basement membrane antibody in the pathogenesis of human glomerulonephritis. J Exp Med. 1967 126 989-1004. 

The major pathologic presentation of solvent associated nephropathy is that of anti-glomerular basement membrane disease [39] but epimembraneous and subacute proliferative glomerulonephritis have also been demonstrated. In addition, Narvarte et al. [40] reported on a patient with ulcerative colitis in which chronic interstitial nephritis developed that later was attributed to long-term exposure to organic solvents. 

Glomerulonephritis induced by by sensitization to heterologous immunoglobulin prior to administration of heterologous anti-glomerular basement membrane immunoglobulin (BALB/c). 

Ig = immunoglobulins GN = glomerulonephritis, GBM = glomerular basement membrane, ANCA = anti-neutrophil cytoplasmic antibodies. Adapted from [25],... 

Tang, W. W., Yin, S., Wittwer, A. J., and Qi, M. (1995). Chemokine gene expression in anti-glomerular basement membrane antibody glomerulonephritis. Am. J. Physiol 269, F323-F330. 

Kain R, Matsui K, Exner M, et al. A novel class of autoantigens of anti-neutrophil cytoplasmic antibodies in necrotizing and crescentic glomerulonephritis the lysosomal membrane glycoprotein h-lamp-2 in neutrophil granulocytes and a related membrane protein in glomerular endothelial cells. J Exp Med 1995 181 585-597. Savage CO, Williams JM. Anti endothelial cell antibodies in vasculitis. J Am Soc Nephrol 2007 18 2424-2426. 

Wilson CB, Dixon FJ. Anti-glomerular basement membrane antibody-induced glomerulonephritis. Kidney Int 1973 3 74—89. 

Fischer, EG, and Lager DJ. Anti-glomerular basement membrane glomerulonephritis a morphologic study of 80 cases. Am J Clin Pathol 2006 125 445-450. 

Beliel OM, Coboum JW, Shinaberger JH, et al. Recurrent glomerulonephritis due to anti-glomerular basement membrane antibodies in two successive allografts. Clin Nephrol 1973 1 377-380. 

Almquist RD, Buckalew VM Jr., Hirszel P, et al. Recurrence of anti-glomerular basement membrane antibody mediated glomerulonephritis in an isograft. Clin Immunol Immunopathol 1981 18 54-60. 

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