Glomerulonephritis proliferative

CHF Congestive heart failure chronic heart failure DPGN Diffuse proliferative glomerulonephritis... 

A 62-year old woman was admitted to hospital with lupus nephritis. A kidney biopsy showed a mesangio-proliferative glomerulonephritis (WHO class III). After 4 months of inadequate response to traditional... 

Of 63 adults with advanced renal insufficiency, those with biopsy-proven primary proliferative glomerulonephritis and those whose clinical presentation was consistent with glomerulonephritis had significantly greater exposure to organic solvents than patients with a variety of other renal diseases (37). 

Lhotta K, Konig P. Cryoglobuhnaemia, membrano-proliferative glomerulonephritis and pANCA in a patient treated with carbamazepine. Nephrol Dial Transplant 1998 13(7) 1890-1. 

Williams AJ, Fordham JN, Barnes CG, Goodwin FJ. Progressive proliferative glomerulonephritis in a patient with rheumatoid arthritis treated with D-petriciUamine. Ann Rheum Dis 1986 45(l) 82-4. 

DotmeUy S, Levison DA, Doyle DV. Systemic lupirs erythematosus-like syndrome with focal proliferative glomerulonephritis during D-penicillamine therapy. Br J Rheumatol 1993 32(3) 251-3. 

Horll Y, Iwano M, HIrata E, Shllkl H, Fuji Y, Dohi K, Ishikawa H. Role of Interleukin-6 in the progression of mesangial proliferative glomerulonephritis. Kidney Int 1993 43 (SuppI 39) S71-S75. 

A drug-induced systemic lupus erythematosus (SEE) with proliferative glomerulonephritis has also been described in patients treated with D-penicillamine [111, 157]. Systemic lupus erythematosus syndrome is induced in approximately 2% of patients treated with D-penicillamine [112,158]. Unlike other forms of drug-induced systemic lupus erythematosus, anti-double-strand DNA anhbodies and/or hypocomplementemia are seen in D-penicillamine-induced systemic lupus erythematosus syndrome [111, 156]. Nephropathy is rare in D-penicillamine-induced systemic lupus erythematosus syndrome [111]. Walshe [112] reported that 8 patients developed the serological change of systemic lupus erythematosus of 120 patients with Wilson s disease treated with D-penicillamine, but none of them showed nephropathy. 

The major pathologic presentation of solvent associated nephropathy is that of anti-glomerular basement membrane disease [39] but epimembraneous and subacute proliferative glomerulonephritis have also been demonstrated. In addition, Narvarte et al. [40] reported on a patient with ulcerative colitis in which chronic interstitial nephritis developed that later was attributed to long-term exposure to organic solvents. 

During the past decade a number of case reports have described the occurrence of different forms of renal disease in patients exposed to silica [58-66]. However, only a few reports concerned subjects exposed to sihca but without silicosis. Most of the cases demonstrated renal lesions compatible with rapidly progressive glomerulonephritis with a necrotizing component present in most cases. Crescent formation was described in a patient with proliferative glomerulonephritis [59] and three individuals with IgA nephropathy [60]. 

Bell GM, Gordon ACH, Lee P, Doig A, MacDonald MK, Thomson D, Anderton JL, Robson JS. Proliferative glomerulonephritis and exposure to organic solvents. Nephron 1985 40 161-165. 

W) Renal cardiac contractility) 28 M (mesangial proliferative glomerulonephritis decreased acid phosphatase in lysosomes of tubular cells) MC... 

Cybulsky AV (2()(X)) Growth factor pathways in proliferative glomerulonephritis. Curr Opin Nephrol Hyper-tens 9 217-223... 

Gilbert RE, Kelly DJ, McKay T, Chadban S, Hill PA, Cooper ME, Atkins RC, Nikolic-Paterson DJ (2001) PDGF signal transduction inhibition ameliorates experimental mesangial proliferative glomerulonephritis. Kidney Int 59 1324-1332... 

Morita Y, Nomura A, Yuzawa Y, et al. The role of complement in the pathogenesis of tubulointerstitial lesions in rat mesangial proliferative glomerulonephritis. J Am Soc Nephrol 1997 8 1363-1372. 

FIGURE 47-9. Treatment algorithm for membranoproliferative proliferative glomerulonephritis. (Modified from Levin. )... 

A drug-induced systemic lupus erythematosus with proliferative glomerulonephritis has also been described in patients treated with D-penidllamine [111,... 

The development of an acute interstitial inflammatory reaction in the kidney related to the administration of certain classes of drugs and leading to renal failure has been recognized for almost a century [42]. Antibiotics, in particular the sulfonamides [43] and semisynthetic penicillins [44, 45], were recognized as etio-logically associated in many instances. A retrospective review of 1068 kidney biopsies from 1%8 to 1997 by Schwarz et al. yielded acute interstitial nephritis in 6.5% of cases. In the majority of instances (85%) acute interstitial nephritis was drug related. Diuretics were implicated in 7.8 % of these cases [46]. Lyons et al. noted that four patients with proliferative glomerulonephritis and nephrotic syndrome treated with sulfonamide-derivative diuretics (furosemide or thiazides) developed severe renal failure, which reversed when the diuretic was withdrawn and prednisone was adminis-... 

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