Globo-series

Scheme 5. Various Glycosyltransfer Reactions Related to the Biosynthesis of Glycosphingolipids having Globo-series Sugar Chains. (Broken arrows indicate the hypothetical, biosynthetic pathway.)...

Some gangliosides of the globo series (Globo-H, sLcx hexasaccharyl ceramide, etc.) are useful cancer cell markers because they are elevated in the membranes of certain types of tumor cells such as melanomas and metastatic brain tumors. A number of GSLs play a role as tumor-associated carbohydrate antigens (TACAs)... 

Kojima Y, Fukumoto S, Fumkawa K, Okajima T, Wiels J, Yokoyama K, Suzuki Y, Urano T, Ohta M, Fumkawa K. Molecular cloning of globotriaosylceramide/CD77 synthase, a glycosyl-transferase that initiates the synthesis of globo series glycosph-ingolipids. J. Biol. Chem. 2000 275 15152-15156. 

Lactosyl ceramide synthase is a pi-4 galactosyl transferase (40). Lactosyl ceramide is the only glycoconjugate that contains lactose (as opposed to lactosamine). Lactosyl ceramide is the substrate for several glycosyl transferases that then define a core sequence of glycosphingolipids. The Globo series is defined by an al-4 galactosyl transferase activity (41, 42) to make initially globotriaosyl ceramide [also defined as the p ... 

JU. Cloning of Gbs synthase, the key enzyme in globo-series 55. glycosphingolipid synthesis, predicts a family of 1,4 glycosyn-transferases conserved in plants, insects and mammals. J. Biol. 56. Chem. 2000 275 25315-25321. 

Murine glycosyltransferases responsible for the expression of globo-series glycolipids cDNA structures, mRNA expression, 63. and distribution of their products. Glycobiology 2005. 

Fig. 17.2 Overview of the biosynthetic pathway of globo-series neutral GSLs and gangliosides.

E. coli adhesin and other bacterial adhesins (globo-series) [44]... 

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