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Galactosyl transferases

Well before the above studies were performed, the biosynthesis of galactosyldiacylglycerol in rat brain had been examined by Wenger et al. (36). These workers found a 3-galactosyl transferase activity capable of catalysing the following reaction ... [Pg.111]

Several compounds have been described by Lehmann s group which have three sugar (or similar) units separated by spacer groupings. For example, compounds 11 and 12 are both acceptors substrates for l,4-/3-galactosyl transferase comparable to the biantennary core heptasaccharide of A/-glycoproteins. Compounds 13 and 14 and 15-17, which are trisaccharides which mimic galactotetraose and maltopentaose, respectively, have been prepared. [Pg.65]

Especially noteworthy is the use of sucrose, Glca(l-2)Fru, as the ultimate source of UDP-Gal. In a first step sucrose synthase from rice cleaves the disaccharide and forms UDP-Glc in the presence of UDP. UDP-Glc is subsequently epimerized at the 4-position by UDP galactose epimerase to give the required UDP-Gal. This donor substrate is first used by P(l-4)galactosyl transferase to produce the N-acetyllactosamine intermediate and then by a(l-3)galactosyl transferase to gal-... [Pg.641]

Scheme 15. 1) sucrose synthase, UTP 2) UDP-glucose-4 -epimerase 3) P(l-4)galactosyl transferase 4) a(l-3)galactosyl transferase. [Pg.642]

FIGURE 6.20 A disaccharide of galactose and glucose is covalently linked to the 5-hydroxyl group of hydroxylysines in collagen by the combined action of the enzymes galactosyl transferase and glucosyl transferase. [Pg.177]

Another interesting point is that glucosyl transferase and galactosyl transferase apparently exerted different activities depending on the blueberry cultivar. ... [Pg.258]

Mutant or knockout mice defective in specific enzymes involved in lipid synthesis have provided powerful tools for genetic analysis of lipid function in the nervous system. For example, disruption of the genes for ceramide galactosyl transferase or galactosyl ceramide sulfotransferase,... [Pg.44]

Monosaccharide attachment to some of the hydroxylysine residues within the a chains occurs at this stage as galactose (gal) and glucose (glc) residues are added by specific galactosyl transferase and glucosyl transferases. The carbohydrates are attached as single monosaccharides or as gal-glc disaccharides. [Pg.292]

Scheme 10.1 Glycopeptide synthesis and a-chymotrypsin catalyzed release from the solid support, a) 25% TFA (CH2CI2) b) 0-(N-Boc-Phe)glycolic acid (7 eq), BOP, HOBt, DIEA b) 25% TFA (CH2CI2) c) Boc-Gly-OH (7 eq), BOP, HOBt, DIEA c) 25% TFA (CH2CI2) d) Boc-Asn(GlcNAcb)-OH (3 eq), BOP, DIEA e) galactosyl transferase, sialyl transferase f) CT, H2O, pH 7.0 g) ultrafiltration h) a-l,3-fuco-syltransferase, GDP-Fuc (2.5 eq), 0.1 M HEPES (pH 7.0), 95%. Scheme 10.1 Glycopeptide synthesis and a-chymotrypsin catalyzed release from the solid support, a) 25% TFA (CH2CI2) b) 0-(N-Boc-Phe)glycolic acid (7 eq), BOP, HOBt, DIEA b) 25% TFA (CH2CI2) c) Boc-Gly-OH (7 eq), BOP, HOBt, DIEA c) 25% TFA (CH2CI2) d) Boc-Asn(GlcNAcb)-OH (3 eq), BOP, DIEA e) galactosyl transferase, sialyl transferase f) CT, H2O, pH 7.0 g) ultrafiltration h) a-l,3-fuco-syltransferase, GDP-Fuc (2.5 eq), 0.1 M HEPES (pH 7.0), 95%.
Scheme 10.2 Oligosaccharide synthesis and a-chymotrypsin catalyzed release from the solid support, a) Z-Phe-NH-(CH2)6-OH (7), CSA, (CHCljjz, 70°C b) Hj, Pd/C, MeOH, 50°C c) CH2 = CHCONH(CHjjsCOOH (8), EtOH-CeHe d) MeONa (cat.), MeOH/THF, CH2 = CHCONH2, TMEDA, APS, DMSO-H2O, SOT e) Galactosyl transferase, Sialyl transferase g) CT, Tris-HCI buffer, pH 7.8, 48 °C, 72% from (10). Scheme 10.2 Oligosaccharide synthesis and a-chymotrypsin catalyzed release from the solid support, a) Z-Phe-NH-(CH2)6-OH (7), CSA, (CHCljjz, 70°C b) Hj, Pd/C, MeOH, 50°C c) CH2 = CHCONH(CHjjsCOOH (8), EtOH-CeHe d) MeONa (cat.), MeOH/THF, CH2 = CHCONH2, TMEDA, APS, DMSO-H2O, SOT e) Galactosyl transferase, Sialyl transferase g) CT, Tris-HCI buffer, pH 7.8, 48 °C, 72% from (10).
LIPOPOLYSACCHARIDE N-ACETYLGLU-COSAMINYLTRANSFERASE LIPOPOLYSACCHARIDE GALACTOSYL-TRANSFERASE... [Pg.757]

Powell, J. T. and Brew, K. 1975. On the interaction of a-lactalbumin and galactosyl-transferase during lactose synthesis. J. BioL Chem. 250, 6337-6343. [Pg.339]

The enzymes involved are nucleoside diphosphohexosetransferases, probably GDP-D-mannosyltransferase (EC 2.4.1.32) and UDP-D-galactosyl-transferase. For a structurally related polymer, (1 - 6)-a-D-xylosyl-(l - 4)-/3-D-glucan, synthesis was shown to involve concurrent incorporation of D-xylose and D-glucose, and not substitution by D-xylose of a preformed (1 - 4)-/3-D-glucan chain.34 The insolubility of (1 - 4)-/3-D-glucan and man-nan would make the latter mechanism unlikely. [Pg.172]


See other pages where Galactosyl transferases is mentioned: [Pg.309]    [Pg.257]    [Pg.202]    [Pg.134]    [Pg.2275]    [Pg.144]    [Pg.1484]    [Pg.580]    [Pg.474]    [Pg.625]    [Pg.336]    [Pg.336]    [Pg.336]    [Pg.336]    [Pg.336]    [Pg.336]    [Pg.642]    [Pg.1307]    [Pg.1388]    [Pg.1416]    [Pg.49]    [Pg.38]    [Pg.420]    [Pg.528]    [Pg.309]    [Pg.168]    [Pg.66]    [Pg.298]    [Pg.146]    [Pg.164]    [Pg.205]    [Pg.105]    [Pg.757]    [Pg.171]    [Pg.45]    [Pg.108]    [Pg.257]    [Pg.81]    [Pg.35]    [Pg.110]    [Pg.161]    [Pg.161]    [Pg.310]    [Pg.141]    [Pg.481]    [Pg.554]    [Pg.554]    [Pg.587]    [Pg.202]    [Pg.246]    [Pg.178]    [Pg.185]    [Pg.219]    [Pg.220]    [Pg.586]    [Pg.348]   
See also in sourсe #XX -- [ Pg.248 ]




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Enzymes galactosyl transferase

Galactolipid galactosyl transferase

Galactosyl transferase reaction catalyzed

Galactosyl transferase substrate specificity

Galactosyl transferases location

Galactosyl transferases type)

Galactosyl-

Galactosylation

Galactosylation, with transferases

Golgi Galactosyl transferase

Lactose galactosyl transferase

Transferases galactosyl transferase

UDP-galactosyl transferase

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