Glioblastoma multiforme tumors

Temozolomide crosses the blood brain barrier and can be used for the treatment of brain tumors (e.g., glioblastoma multiforme). The most common side effects are nausea and vomiting. 

Kleinberg, L, Grossman, S.A., Carson, K., Lesser, G., O Neill, A., Pearlman, J., Phillips, P., Herman, T., and Gerber, M. Survival of patients with newly diagnosed glioblastoma multiforme treated with RSR13 and radiotherapy results of a phase 11 new approaches to brain tumor therapy CNS consortium safety and efficacy study. J. Clin. Oncol. 2002, 20, 3149-3155. 

Mazzoleni S, Politi LS, Pala M et al (2010) Epidermal growth factor receptor expression identifies functionally and molecularly distinct tumor-initiating cells in human glioblastoma multiforme and is required for gliomagenesis. Cancer Res 70 7500-7513... 

Although the efficiency of transfection was 18.6% in vivo after intratumoral injection of DNA liposomal complexes, the sensitivity to ganciclovir was improved as tumor weight induction was observed. In 2001, the FDA approved a clinical protocol relevant to liposomal gene therapy with the HSVtk/GCV system for the treatment of glioblastoma multiforme [408],... 

The IR spectra (traces A-C) in Figure 3.2 demonstrate the effect of treating tissue sechons with polar and nonpolar solvents. The IR spectrum (trace A) was obtained from a dried tissue section of a glioblastoma multiforme (GBM) brain tumor. Compared to the spectra in Figure 3.1, it is evident that this hssue is mainly composed of proteins and lipids. The IR spectrum (trace B) was acquired from a consecuhve hssue sechon that had been treated for 10 min with a drop of toluol. The overlay of the normalized spectra indicates that Upid-assodated bands at 1740,... 

Figure 3.7 (a-k) FT-IR images often brain tissue sections obtained from a brain tumor patient with a multifocal glioblastoma multiforme. The color code represents the classification by a LDA model into six classes regular (green), low increased (blue),... 

An analogous application in which RIT has yielded encouraging results is in the treatment of MRD in brain malignancies [52]. Glioblastoma multiforme (GBM) is one of the most deadly and rapidly growing tumors, and patients generally have a... 

Gene Therapy for the Treatment of Recurrent Glioblastoma Multiforme with In Vivo Tumor Transduction with the Herpes Simplex-Thymidine Kinase Gene/Ganciclovir System... 

---