Glaser

Created by Rainer Glaser (University of Missouri) the animations are basic mechanisms that can be presented at full screen size m your classroom The animations on the CD can be played directly from the CD or can be im ported easily into your own lecture presentation... 

P. E. Glaser, Solar-Power Satellites The Emerging Energy Option, Ellis Howard, New York, 1993. 

Glaser and Thodos [Am. Jn.st. Chem. Eng. J., 4, 63 (1958)] give a correlation involving individual particle shape and bed porosity. Kunii and Suzuki [Jnt. ]. Heat Mass Tran.sfer, 10, 845 (1967)] discuss heat and mass transfer in packed beds of fine particles. 

GLASER - CHODKIEWCZ Acetylene Coupling Polyacetylenes from monoacetylenes in the presence of copper salts. 

Towler, D. A., Gordon, J. L, Adams, S. R, and Glaser, L., 1988. The biology and enzymology of eukaryodc protein acylation. Annual Review of Biochemistry 57 69—99. 

The Glaser reaction is an oxidative coupling of terminal alkynes 1 to yield a symmetrical Z -acetylene 2 the coupling step is catalyzed by a copper salt. Closely related is the Eglinton reaction, which differs from the Glaser reaction mainly by the use of stoichiometric amounts of copper salt as oxidizing agent. 

Acetylene and terminal alkynes are CH-acidic compounds the proton at the carbon-carbon triple bond can be abstracted by a suitable base. Such a deprotonation is the initial step of the Glaser reaction as well as the Eglinton... 

The Glaser coupling reaction is carried out in aqueous ammonia or an alcohol/ammonia solution in the presence of catalytic amounts of a copper-I salt. The required copper-II species for reaction with the acetylide anion R-C=C are generated by reaction with an oxidant—usually molecular oxygen. For the Eglinton procedure, equimolar amounts of a copper-II salt are used in the presence of pyridine as base. 

All three coupling procedures are suitable to give high yields under mild reaction conditions. Many functional groups do not interfere. For the application in organic synthesis the Eglinton variant may be more convenient than the Glaser method a drawback however is the need for stoichiometric amounts of copper salt. 

Glaser oxidative coupling, 46, 41 Glucqfvranosyl chloride, 2 ACET AMIDO 2 DEOXY TRIACETATE,... 

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