Glaser modified

NOTE - Glasers use a light bullet driven at high velocity. Any significant increase in weightcould cause excessive chamber pressure to develop. Use caution. The only one I can recommend as safe is the modified. 38 Special when fired in the. 357 Magnum, The. 357 will easily handle the pressures developed by the. 38 cartridge. 

Poison Bullet 3 Modified Glaser Safety Slug... 

In the Hay modification of the Glaser reaction, it was noted that the reaction could be modified to avoid isolation of the acetylide ... 

Diacetylene-bridged dimers 18, 25, and 28 were more conveniently prepared (47-68% yields after Zemplen treatment) by a modified Glaser (27) oxidative homocoupling under Hay s conditions (28) of the corresponding ethynylphenyl mannosides using copper(II) acetate in refluxing pyridine (48 h.). 

The oxidative coupling of acetylenes, reported originally by Glaser and subsequently modified by others, has played a major role in the development of polyacetylene chemistry. The reaction has been reviewed comprehensively, and these reviews should be consulted for details and lists of earlier references -... 

The oxidative coupling of terminal alkynes by copper salts, discovered in 1869 by Glaser, has evolved to the modified method reported in 1962 by Hay. In the Hay procedure, oxygen is passed through a solution of the alkyne and a catalytic amount of a copper(I) salt in a complex-forming solvent, such as pyridine and TMEDA. Although the oxidative coupling by Cu salt catalysts in suitable amines has wide scope, it is less successful for less acidic terminal alkynes, such as alkyl- or silyl-alkynes. 

Kiecolt-Glaser, J. K. et al. (1984a). Psychosocial modifiers of immunoincompetence in medical students. Psychosomatic Medicine 46 7-14. 

Tilley and co-workers (86) proposed a new mechanism (called the Glaser-Tilley mechanism), which involves activation of two (sp ) Si—H bonds of the silane substrate, direct addition of (sp ) Si—H to alkene and finally the 1,2-H-migration and reductive elimination step (Scheme 12). Theoretical study by Beddie and Hall (87) showed that the highest energy transition state in this novel mechanism is more than 8 kcal/mol lower in energy than the highest energy transition states in the Chalk-Harrod and modified Chalk-Harrod mechanisms. 

Glaser B. PrehistoricaUy modified soils of central Amazonia, a model for sustainable agriculture in the twenty-first century. Philos Trans R Soc B-Biol Sci 2007 362(1478) 187—96. 

O Donoghue ML, Glaser R, Aylward PE et al (2015) Rationale and design of the LosmApimod to inhibit p38 MAP kinase as a Therapeutic target and moDify outcomes after an acute coronary syndromE trial. Am Heart J 169 622-630.e6... 

Glaser R.H., Wilkes G.L. Polymer-modified mixed metal alkoxide-metal acetyl acetonate sol-gel materials. Polym. Bull. 1989 22 527-532... 

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