Gillis

Chapter 8. Vasodilator and Vasoconstrictor Agents F. P. Hauck and C. N. Gillis 

Drugs with Predominantly Direct Action - Octapressin, a syn-thetic analog of lysine vasopressin, has been studied in conditions of hypotension in man. In low doses, the peptide caused renal vasodilatation while higher doses resulted in preferential extrarenal vasoconstriction with consequent redistribution of blood flow to the kidney. Accordingly, the drug may have application in conditions associated with hypotension and renal vasoconstriction (a combination that very often coexists in conditions of shock ). Octapressin has been used in the past clinically and experimentally to treat circulatory shock and is particularly effective in microcircula-tory failure.  

A series of bradykinin analogs containing the simple secondary amino acid, sarcosine, in place of the cyclic secondary structure, proline, was prepared to determine whether modification of the biologic activity of bradykinin might be related to steric factors. 2-Sarcosine bradykinin was the most active analog in increasing hind limb blood flow in the dog, although its activity was at most only about 30% that of synthetic bradykinin. The 3-sarcosine derivative of bradykinin 

Kallidin, the lysine-homologue of bradykinin, was as effective as bradykinin in increasing digital volume in man O both peptides may act by closure of arterial venous anastomosis which results in shunting of blood into capillary beds. 

Bradykinin not only dilates arterioles but is thought to be linked with another accompaniment of the early inflammatory response, namely increased vascular permeability . The effect of several bradykinin analogs on vascular permeability was studied in guinea pigslS. Lysine bradykinin (kallidin) was more effective in increasing vascular permeability than was bradykinin itself. Glycyl bradykinin had about the same degree of activity as the parent compound, while all others were less active. 

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Gillis H P, Choutov D A and Martin K P 1996 The dry etching of Group Ill-Nitride wide bandgap semiconductors J. Mater. 48 50-5... 

Gillis H P, Choutov D A, Steiner P A IV, Piper J D, Crouch J H, Dove P M and Martin K P 1995 Low energy electron enhanced etching of Si(IOO) in hydrogen-helium DC plasma App/. Phys. Lett. 66 2475-7... 

Gillis H P, Choutov D A, Martin K P, Pearton S J and Abernathy C R 1996 Low energy electron enhanced etching of GaN/Si in hydrogen DC plasma J. Electrochem. Soc. 143 L251-4... 

M. T. Gillies, Shortenings, Margarines, andFood Oils, Noyes Data Corp., Park Ridge, N.J., 1974, pp. 219—220. 

S-Butyryl thiocholine iodide [(2-butyrylmercaptoethyl)trimethyl ammonium iodide] [1866-16-6] M 317.2, m 173", 173-176". Recrystd from propan-l-ol and dried in vacuo store in the dark under N2. The bromide has m 150° (from Me2CO) or m 140-143° (from butan-l-ol). [Gillis Chem and Ind (London) 111 1957 Hansen Acta Chem Scand 11 537 1957.]... 

AX(B)1004 V. Bertolasi, P. Gilli, V. Ferretti, and G. Gilli, Acta Crystallogr. B 51,... 

F. E. ZiE-TLER, P.. Gilli-tam,/. Oig. Cheiv. 19S1, 46, 3S74-3SS0. 

Gillis, J. R., Testing for Explosiveness of Dusts, Loss Prevention, Vol. 2, Amer. Inst. Chem. Engr., 1968, p. 34. 

Mass Spectra. Obtained by Gillis et al (Ref 104). Field ionization and electron impact ionization mass spectra are given by Brunee et al (Ref 54) Mechanical Properties < Sound Velocity. Hoge (Ref 77) obtained the following ultimate stress as a function of strain rate for machined discs (1.77g/cc) of PETN (all failures were brittle fractures)... 

Haas, D. B., Gillies, R., Small, M. and Husband, W. H. W. Saskatchewan Research Council publication No. E-835-1-C80 (March 1980). Study of the hydraulic properties of coarse particles of metallurgical coal when transported in slurry form through pipelines of various diameters. 

Navarini L, Gilli R, Gombac V, Abatangelo A, Bosco M, Toffanin R (1999) Carbohydr Polym 40 71... 

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