Germ-cell tumors metastatic

Yu H, Pinkus GS, Hornick JL. Diffuse membranous immunore-activity for podoplanin (D2-40) distinguishes primary and metastatic seminomas from other germ cell tumors and metastatic neoplasms. Am J Clin Pathol. 2007 128 767-775. 

Saad RS, Landreneau RJ, Liu Y, et al. Utility of immunohis-tochemistry in separating thymic neoplasms from germ cell tumors and metastatic lung cancer involving the anterior mediastinum. Appl Immunohistochem Molec Morphol. 2003 11 107-112. 

Iczkowski KA, Butler SL, Shanks JH, et al. Trials of new germ cell immunohistochemical stains in 93 extragonadal and metastatic germ cell tumors. Hum Pathol. 2008 39 275-281. 

Extratestlcular Primary Germ Cell Tumors and Metastatic Germ Cell Tumors... 

Important characteristics of carcinoma as it relates to the CNS and meninges are its distinctively epithelial structure (Fig. 20.58A see Table 20.6) and the overwhelming predominance of metastatic over primary carcinomas. Metastatic carcinomas are described in detail in Chapter 8, Immunohistology of Metastatic Carcinomas of Unknown Primary. Rare primary brain carcinomas occur in the choroid plexus, from germ cell tumors of the pineal and suprasellar regions, and from cysts. 725 section emphasizes how to distinguish between carcinomas (see Fig. 20.58B to D) and various primary intracranial tumors (see Box 20.2). 

In addition to the sex-cord stromal tumors, a variety of other benign and primary and metastatic malignant ovarian tumors may have a functioning stroma with estrogenic or androgenic production. However, these elevations will remain commonly subclinical. These tumors include mucinous tumors, rarely endometrioid carcinoma, malignant germ cell tumors, and mucinous metastatic carcinomas [37]. 

Cheng L. Establishing a germ cell origin for metastatic tumors using OCT4 immunohistochemistry. Cancer. 2004 101 2006-2010. 

Kernek KM, Brunelli M, Ulbright TM, et al. Fluorescence in situ hybridization analysis of chromosome 12p in paraffin-embedded tissue is useful for establishing germ cell origin of metastatic tumors. Mod Pathol. 2004 17 1309-1313. 

Dennis, J. W. (1985). Partial reversion of the metastatic phenotype in a wheat germ agglutinin-resistant mutant of the murine tumor cell line MDAY-D2 selected with Bandeiraea simplicifolia seed lectin. J. Natl. Cancer Inst. 74, 111 1-1120. 

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