Geometric cues

Kilian KA, Bugarija B, Lahn BT, Mrksich M (2010) Geometric cues for directing the differentiation of mesenchymal stem cells. Proc Natl Acad Sci U S A 107(11) 4872-4877... 

Kilian, K.A., Bugarija, B., Lahn, B.T., Mrksich, M., 2010. Geometric cues fordhecting the differentiation of mesenchymal stem cells. Proceedings of the National Academy of Sciences of the United States of America 107, 4872 877. 

Experience has shown that retrieval based on 3D geometric cues often returns structures in very different chemical classes as compared with the compound from which the query originated. For additional information see also Conformational Flexibility in 3D Structure Searching and Three-dimensional Structure Searching. 

Ripamonti, U. M. D. P. D., Richter, P. W. R. D., and Thomas, M. E. P. D. 2007. Self-inducing shape memory geometric cues embedded within smart hydroxyapatite-based biomimetic matrices. Plastic Recons Surg, 120,1796-1807. 

Piloting with landmarks Although the Cheng experiment showed that animals can be almost completely dependent on the visual appearance of the geometric frame of an environment, other research indicates that animals also use isolated cues within an environment to guide their travel to particular locations. For example, rats placed within a cylindrical environment that provides no locations that are distinguished by the environmental frame still are able to locate rewarded and nonrewarded arms on a radial maze, if distinct visual cues are attached to the wall surrounding the maze (Suzuki et al., 1980). 

Geometrical, Topographical, and Mechanical Cues on Stem Cell Fate in a Micro-/Nano-environment... 

Geometrical refers to the shape and form of a surface, while topographical refers to the three-dimensional physical configuration of the surface. On the other hand, mechanical refers to the varying stiffness and rigidity of biomaterials. These cues provide signals to influence stem cell configuration and differentiation. 

Geometrical, Topographical, and Mechanical Cues substrates with (a) microcontact printing, (b) photo-on Stem Cell Fate in a Micro-ZNano-environment, patterning, and (c) laser patterning Fig. 1 Micropatteming of glass or plastic culture... 

This sequence allowed us to produce well-defined 3D polymeric microstructures with arbitrary binary protein patterns (Figure 9.3). Such materials can find applications in the area of cell biology, in particular to manipulate the fate of cells as it is known that their behavior depends on geometrical, mechanical and chemical external cues. 

The in vitro release from Cue-Mate and TRIU-B Cronipres can be predicted by considering it as a release from a complex geometry device. Due to the complexity of the geometric shape of the device, no analytical solution can be obtained for this system. Numerical methods, like the finite element method, must be used for modeling the release from this device [190]. Examples of mathematical modeling using numerical methods for complex geometry devices can be found in the literature [191-195]. 

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