Gentamicin-prednisone

Although topical antibiotics are used frequently in the management of ocular rosacea, no firm evidence demonstrates their efficacy as a sole therapeutic agent. Topical steroids, however, are effective for treating the inflammatory aspects and frequently are used four times daily in conjimction with antibiotics in combination products such asTobraDex (tobramycin-dexamethasone), Pred-G (gentamicin-prednisone), or Maxitrol (neomycin-polymyxin B-dexamethasone). Because of potential steroid-induced side effects, chronic use of these agents should be avoided. 

Clinically important, potentially hazardous interactions with aminoglycosides, cortisone, cyclopropane, enflurane, gentamicin, halothane, hydrocortisone, isoflurane, kanamycin, methoxyflurane, mivacurium, neomycin, piperacillin, prednisolone, prednisone, streptomycin, tobramycin... 

Broughton et al. (180) have demonstrated that the use of nonspecific antisera to gentamicin could also be applied to the analysis of sisomicin if gentamicin were not present in the samples, because cross-reactivity with other substances was minimal. We have successfully used anti-prednisone antiserum to measure cortisone in serum in the absence of prednisone. This was possible because crossreactivity with other compounds was not significant (181). 

Hydrocortisone, prednisone, fludrotisone, triamcinolone, dexamethasone, betamethasone Penicillins, cephalosporins, vancomycin, bacitracin, polymycins, tetracyclines, chloramphenicol, erythromycin, streptomycin Quinacrine, chloroquine, quinine Nystatin, gentamicin, miconazole, tolnaftate, undecyclic acid and its salts Vidarabine, acyclovir, ribarivin, amantadine hydrochloride, iododeoxyuridine, dideoxyur-idine, interferons... 

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