Genotoxicity, of organotin compounds

Hamasaki T, Sato T, Nagase H, Kito H (1992) The genotoxicity of organotin compounds in SOS chromotest and rec-assay. Mutation Research, 280(3) 195-203. 

Organotin derivatives exhibit genotoxic, neurotoxic, immunotoxic and hepatotoxic effects. It is important to study the genotoxicity of tin compounds, as they have the... 

As shown in Tables 2-7 and 2-8, there are both in vitro and in vivo genotoxicity data for organotin compounds, particularly bis(tributyltin)oxide. The results from most in vitro studies were negative. However, base-pair substitutions were produced in an activated Salmonella typhimurium fluctuation test of bis(tributyltin)oxide (Davis et al. 1987). In addition, bis(tributyltin)oxide produced chromosomal aberrations in hamster ovary cells with activation (Davis et al. 1987). In vivo micronucleus tests of bis(tributyltin)oxide in mice produced mixed results (Table 2-8). The relevance of the genotoxic data to humans is not clear. 

The extent of the database on health effects in animals resulting from exposure to organotin compounds is clearly shown in Figure 2-5. Except for genotoxic studies, there are oral studies that describe all the other toxicological end points considered in this profile. By contrast, the information is more limited for the inhalation and dermal routes of exposure. 

Genotoxicity. There are no human data regarding the genotoxic potential of inorganic tin or organotin compounds after inhalation, oral, or dermal exposures. The limited in vitro data on inorganic tin... 

Dixon, D.R. and H. Prosser. 1986. An investigation of the genotoxic effects of an organotin antifouling compound (bis (tributyltin) oxide) on the chromosomes of the edible mussel, Mytilus edulis. Aquat. Toxicol. 8 185-195. 

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