Genomic sequencing

The International Human Genome Sequencing Consor tium was headed by Francis S Collins of the U S National Institutes of Health J Craig Venter led the Celera effort... 

The human genome sequence has been called the book of life and more modestly a tool box and an instruction manual Regardless of what we call it it promises a future characterized by a fuller understanding of human biology and medical science... 

Genome (Section 28 7) The aggregate of all the genes that de termine what an organism becomes Genomics (section 28 15) The study of genome sequences and their function... 

DT Jones. Genthreader An efficient and reliable protein fold recognition method for genomic sequences. J Mol Biol 287 797-815, 1999. 

With the realization that there are only a limited number of stable folds and many unrelated sequences that have the same fold, biologically oriented computer scientists started to address what is called the inverse folding problem namely, which sequence patterns are compatible with a specific fold If this question can be answered, such patterns could be used to search through the genome sequence databases and extract those sequences that have a specific fold, such as the cx/p barrel or the immunoglobulin fold. 

Genomics (section 28.15) The study of genome sequences and their function. 

That bacterial resistance predates the era of clinical use of antibiotics by several hundred millions of years is the recent result of genomic sequence data mining from antibiotic-producing microorganisms. These are supposed to be the inventors of antibiotic resistance genes which they had developed to protect themselves from the lethal action of their own antibiotics [4]. 

Interestingly, the genomic sequences of all AMPA receptor subunits contain a Q codon for this position and the R codon is selectively introduced into the GluR-B pre-mRNA by RNA editing [3]. Additionally, the Q/R site is a critical determinant of current... 

The constantly increasing amount of data coming from high throughput experimental methods, from genome sequences, from functional- and structural genomics has given a rise to a need for computer-assisted methods to elucidate sequence-structure-function relationships. 

Protein sequences encoded by genome sequences encode biological functions. 

With the onset of genomic biology, there are now many sequences derived from genome sequencing projects that are too divergent to be considered species variants of known peptidases. Of the 54,124 sequences in the MEROPS database only 18,741 (34.6%) have been assigned to an identifier. 

Genome sequencing revealed approximately 100 human PTP genes [2], compared with 90 human protein tyrosine kinase genes, suggesting similar levels of complexity among the opponents. The catalytic domain... 

International Human Genome Sequencing Consortium. Finishing the euchro-matic sequence of the human genome. Nature 2004 431 931-45. 

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