Mining Genome Sequence Data

Thanks to the recently completed, or to the ongoing genome sequencing projects for hydrogenosomal and mitosomal species (McArthur et al. 2000 Katinka et al. 2001 Abrahamsen et al. 2004 Xu et al. 2004 Loftus et al. 2005  

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That bacterial resistance predates the era of clinical use of antibiotics by several hundred millions of years is the recent result of genomic sequence data mining from antibiotic-producing microorganisms. These are supposed to be the inventors of antibiotic resistance genes which they had developed to protect themselves from the lethal action of their own antibiotics [4]. 

Attempts to manage specialized scientific information have given birth to the new discipline of informatics. The branch of informatics that deals primarily with genomic (sequence) data is bioinformatics, whereas cheminformatics deals with chemically oriented data. Informatics examines the way people work with computer-based information. Computers can access huge warehouses of information in the form of databases. Effective mining of these databases can, in principle, lead to knowledge. 

KING, R.D., KARWATH, A., CLARE, A., DEHASPE, L., Accurate prediction of protein functional class from sequence in Mycobacterium tuberculosis and Escherichia coli genomes using data mining, Yeast, 2000,17, 283-293. 

Recent advances in sequencing technologies have fostered the capacity to sequence large and complex genomes, ESTs, and other libraries, leading to an exponential increase in the volume of DNA and protein sequence data available in sequence databases. Predicting the function of an unknown protein by sequence or motif similarity to a previously characterized protein is an extremely valuable process and is the lynchpin in the data mining approach to... 

ARAKAWA, K., MORI, K., IKEDA, K., MATSUZAKI, T., KOBAYASHI, Y., TOMITA, M., G-Language Genome Analysis Environment A workbench for nucleotide sequence data mining.. Bioinformatics, 2003,19, 305-306... 

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