Human genome project sequence

The promise of being able to predict and modify the genetic characteristics of an organism fuelled massive efforts to determine the base sequences of human genes. The human genome project has now reached the goal of sequencing all the important DNA carried by humans. 

Anon (2001b), The Human Genome. International Human Genome Project Consortium sequence , Science, February 15 [CD-ROM with instructional materials included]. 

Xiao H, Merril, CR, Wu A, Olde B, Moreno R, Kerlavage AR, McCombie WR, Venter JC. Complementary DNA sequencing Expressed Sequence Tags and the Human Genome Project. 

One driver for new discovery will be the completion of the human genome project. As a result of this project, the locations and sequences associated with the tens of thousands of genes of the human genome will have been determined. In the post-genomic era, then, we will know the DNA sequences and genes of a human being, but that is only the start. What are the functions associated with these sequences We will need to isolate the proteins that are the gene products,... 

The year 2000 marked the completion of the Human Genome Project s primary goal. Through intensive efforts of both private and public agencies, the sequence for the three billion base pairs that encodes the instructions for being human has now been determined.5 As a result of the Human Genome Project, we have determined the complete chemical structure, nucleotide by nucleotide, of the DNA within each of these chromosomes, the chemical structures that encode our lives. It is an extraordinary accomplishment in chemistry. 

H4 receptors are very similar to H3 receptors in gene structure and signal transduction, but show limited expression in the brain. The H4 receptor gene was identified in 2000 as a direct consequence of the human genome project. Use of the human H3 receptor sequence led to the identification of a related orphan GPCR. 

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